Biology Faculty Articles

Document Type

Article

Publication Date

12-8-2019

Publication Title

International Annals of Science

Keywords

14-3-3, YWHA, Drosophila, Signaling, Development

ISSN

2456-7132

Volume

9

Issue/No.

1

First Page

80

Last Page

85

Abstract

The 14-3-3 (YWHA or Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation proteins) are a family of highly conserved, homologous proteins critical to diverse cellular events including cell cycle, signal transduction and embryonic development. Various species-specific isoforms of 14-3-3 exist, encoded by separate genes. They are expressed in a wide variety of organisms ranging from plants to animals, including the fruit fly or Drosophila melanogaster. Drosophila is one of the most universally accepted model systems to study complex cellular mechanisms of signalling and development. However, regulation of these processes in fruit flies by the 14-3-3 proteins have not been entirely understood. This mini review encapsulates the expression, distribution, interactions and regulatory roles of the 14-3-3 proteins in Drosophila. The analysis would help to elucidate some of the molecular bases of key cell-signalling mechanisms and development.

Comments

Copyright © 2019. The Author(s). Published by AIJR Publisher. This is an open access article under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license, which permits any non-commercial use, distribution, adaptation, and reproduction in any medium, as long as the original work is properly cited.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

ORCID ID

0000-0002-9739-4039

DOI

10.21467/ias.9.1.80-85

Peer Reviewed

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