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Marine & Environmental Sciences Faculty Articles
ORCID
0000-0002-1637-4125
ResearcherID
F-8809-2011
Document Type
Article
Publication Title
Journal of Natural Products
ISSN
0163-3864
Publication Date
2006
Keywords
Ascomycota, Candida albicans, Leukemia P388, Microbial Sensitivity Tests, Pyrroles, Molecular Structure
Abstract
As part of our ongoing chemical investigation of biologically active metabolites from marine fungi, three new compounds, p-hydroxyphenopyrrozin (1) and diketopiperazines (3, 4), have been isolated from the marine-derived fungus Chromocleista sp. In addition, the fungus gave the known compound phenopyrrozin (2), four known diketopiperazines (6-9), N-acetyltryptamine (10), and agathic acid (11). Another new diketopiperazine (5) was separated and identified as a decomposition product of 3 and 4. The structures of the new metabolites were determined on the basis of mass spectroscopy, NMR experiments, and derivatization methods. The absolute configuration of 1 was determined by X-ray crystallography studies.
DOI
10.1021/np058113p
Volume
69
Issue
4
First Page
580
Last Page
584
NSUWorks Citation
Park, Young Chul, Sarath P. Gunasekera, Jose V. Lopez, Peter J. McCarthy, and Amy E. Wright. "Metabolites from the marine-derived fungus Chromocleista sp. isolated from a deep-water sediment sample collected in the Gulf of Mexico." Journal of natural products 69, no. 4 (2006): 580-584.
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Comments
©2006 American Chemical Society and American Society of Pharmacognosy