Metabolites from the Marine-Derived Fungus Chromocleista sp. Isolated from a Deep-Water Sediment Sample Collected in the Gulf of Mexico

Authors

Young Chul Park, Harbor Branch Oceanographic Institution
Sarath P. Gunasekera, Harbor Branch Oceanographic Institution
Jose V. Lopez, Harbor Branch Oceanographic InstitutionFollow
Peter J. McCarthy, Harbor Branch Oceanographic Institution
Amy E. Wright, Harbor Branch Oceanographic Institution

ORCID

0000-0002-1637-4125

ResearcherID

F-8809-2011

Document Type

Article

Publication Title

Journal of Natural Products

ISSN

0163-3864

Publication Date

2006

Keywords

Ascomycota, Candida albicans, Leukemia P388, Microbial Sensitivity Tests, Pyrroles, Molecular Structure

Abstract

As part of our ongoing chemical investigation of biologically active metabolites from marine fungi, three new compounds, p-hydroxyphenopyrrozin (1) and diketopiperazines (3, 4), have been isolated from the marine-derived fungus Chromocleista sp. In addition, the fungus gave the known compound phenopyrrozin (2), four known diketopiperazines (6-9), N-acetyltryptamine (10), and agathic acid (11). Another new diketopiperazine (5) was separated and identified as a decomposition product of 3 and 4. The structures of the new metabolites were determined on the basis of mass spectroscopy, NMR experiments, and derivatization methods. The absolute configuration of 1 was determined by X-ray crystallography studies.

DOI

10.1021/np058113p

Volume

69

Issue

4

First Page

580

Last Page

584

Comments

©2006 American Chemical Society and American Society of Pharmacognosy

NSUWorks Citation

Park, Young Chul, Sarath P. Gunasekera, Jose V. Lopez, Peter J. McCarthy, and Amy E. Wright. "Metabolites from the marine-derived fungus Chromocleista sp. isolated from a deep-water sediment sample collected in the Gulf of Mexico." Journal of natural products 69, no. 4 (2006): 580-584.