Title

Changes in Motoric, Exploratory, and Emotional Behaviours and Neuronal Acetylcholine Content and 5-HT Turnover in Histidine Decarboxylase-KO Mice

Document Type

Article

Publication Date

2004

Publication Title

European Journal of Neuroscience

Keywords

Acetylcholine, Arousal, Habituation, Histamine, Knockout

ISSN

0953-816X

Volume

20

Issue/No.

4

First Page

1051

Last Page

1058

Abstract

Histamine has been implicated, inter alia, in mechanisms underlying arousal, exploratory behaviour and emotionality. Here, we investigated behavioural and neurochemical parameters related to these concepts, including open-field activity, rotarod performance and anxiety, as well as brain acetylcholine and 5-HT concentrations of mice deficient for the histidine decarboxylase (HDC) gene. These mice are unable to synthesize histamine from its precursor histidine. The HDC-knockout mice showed reduced exploratory activity in an open-field, but normal habituation to a novel environment. They behaved more anxious than the controls, as assessed by the height–fear task and the graded anxiety test, a modified elevated plus-maze. Furthermore, motor coordination on the rotarod was superior to controls. Biochemical assessments revealed that the HDC-knockout mice had higher acetylcholine concentrations and a significantly higher 5-HT turnover in the frontal cortex, but reduced acetylcholine levels in the neostriatum. These results are suggestive of important interactions between neuronal histamine and these site-specific neurotransmitters, which may be related to the behavioural changes found in the HDC-deficient animals.

Comments

©2004 Federation of European Neuroscience Societies

DOI

10.1111/j.1460-9568.2004.03546.x

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