Faculty Articles
Title
Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome
ISBN or ISSN
0006-3223
Publication Title
Biological Psychiatry
Volume
32
Issue
9
Publication Date / Copyright Date
11-1-1992
First Page
834
Last Page
838
DOI Number
10.1016/0006-3223(92)90087-G
Abstract
Chronic fatigue syndrome (CFS) includes many symptoms of major depression. For this reason, many antidepressants have been used to treat the symptoms of this disorder. Among the more recently released antidepressants are fluoxetine and bupropion. In this open study, nine CFS patients who either could not tolerate or did not respond to fluoxetine showed significant response when administered 300 mg/day of bupropion for an 8-week period in both rating of HDRS (t = 4.80, p < 0.01) and BDI (t = 2.48, p < 0.05). Furthermore, bupropion improvement in Hamilton Depression Rating Scale correlated significantly with change in plasma homovanillic acid (HVA) (r = 0.96, p < 0.01). Plasma total methylhyroxyphenolglycol (MHPG) also increased significantly during bupropion treatment (t = 2.37, p = 0.05). Measures of T1 microsomal antibodies also decreased over treatment time; increases in natural killer cell numbers correlated inversely with change in plasma levels of free MHPG (r = −0.88, p < 0.05). Bupropion responders were more likely to have trough blood levels above 30 ng/ml (X2 = 3.6, p = 0.05).
Disciplines
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
NSUWorks Citation
Goodnick, P. J.; Sandoval, R.; Brickman, A.; and Klimas, Nancy G., "Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome" (1992). Faculty Articles. 435.
https://nsuworks.nova.edu/hpd_com_faculty_articles/435
