Biology Faculty Articles

Title

Long-Term Nonprogressive Infection with Human Immunodeficiency Virus Type 1 in a Hemophilia Cohort

Document Type

Article

Publication Date

12-1999

Publication Title

The Journal of Infectious Diseases

ISSN

0022-1899

Volume

180

Issue/No.

6

First Page

1790

Last Page

1802

Abstract

Seven long-term nonprogressors (LTNPs) have been identified in a cohort of 128 human immunodeficiency virus (HIV)-1 infected individuals with hemophilia. Studies included quantitation of virus by polymerase chain reaction, characterization of primary virus isolates in vitro, analysis of lymphocyte surface markers, and measurement of virus-specific cytotoxic T lymphocytes (CTLs). Viruses of LTNPs exhibited slow growth in vivo and in vitro. LTNPs had expansion of CDS T cells with increased expression of HLA-DR. Intermittent HIV- 1-specific CTL effector activity was detected in freshly isolated peripheral blood mononuclear cells of most LTNPs. CTL precursor frequencies were higher in LTNPs than in patients with progressive disease. Virus antigen-specific lymphoproliferation was vigorous in some LTNPs. Thus, LTNPs in this cohort have maintained remarkably low virus burdens and vigorous HIV-1-specific cell-mediated immunity over a 15-year period. The presence of expanded, activated CDS T cells with cytotoxic effector function in the peripheral blood suggests ongoing viral replication.

Comments

©1999 by the Infectious Diseases Society of America

Additional Comments

NIH grant #s: HL-22257, AI-26057, AI-39400, AI-01382

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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