Biology Faculty Articles

Title

Genetics of HIV-1 Infection: Chemokine Receptor Ccr5 Polymorphism and its Consequences

Document Type

Article

Publication Date

1999

Publication Title

Human Molecular Genetics

ISSN

0964-6906

Volume

8

Issue/No.

10

First Page

1939

Last Page

1945

Abstract

The chemokine receptor gene, CCR5, has become a central theme in studies of host genetic effects on HIV-1 pathogenesis ever since the discovery that the CCR5 molecule serves as a major cell surface co-receptor for the virus. A growing number of genetic variants within the coding and 5′ regulatory region of CCR5 have been identified, several of which have functional consequences for HIV-1 pathogenesis. Here we review the CCR5 literature describing CCR5 polymorphism and the functional ramifications that several of these variants have on HIV-1 infection and progression to AIDS. The multiplicity of CCR5 genetic effects on HIV-1 disease underscores the critical importance of this gene in controlling AIDS pathogenesis and provides the logic for development of therapeutic strategies that target the interaction of HIV-1 envelope and CCR5 in HIV-1 associated disease.

Comments

©1999 Oxford University Press

Additional Comments

NCI contract #: NO1-CO-56000

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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