Biology Faculty Articles

Title

Racial Differences in HLA Class II Associations with Hepatitis C Virus Outcomes

Document Type

Article

Publication Date

7-1-2001

Publication Title

Journal of Infectious Diseases

ISSN

0022-1899

Volume

184

Issue/No.

1

First Page

16

Last Page

21

Abstract

A broad, vigorous CD4 T cell response, mediated by class II human leukocyte antigens (HLAs), favors hepatitis C virus (HCV) clearance. HLA-DQB1*0301 has been associated with viral clearance in an ethnically homogeneous cohort. To validate this association and to identify other class II associations in an ethnically varied cohort, molecular class II HLA typing was performed on 200 HCV clearance and 374 matched persistently infected subjects. HLA-DQB1*0301 was weakly associated with viral clearance in combined ethnic groups (odds ratio [OR], 0.72; 95% confidence interval [CI], 0.53–0.97) but was stronger in black subjects. In white subjects, viral clearance was associated with DRB1*0101 (OR, 0.32; 95% CI, 0.17–0.60) and its DQB1*0501 haplotype, whereas viral persistence was associated with DRB1*0301 (OR, 2.36; 95% CI, 1.23–4.52) and its DQB1*0201 haplotype. These results support a role for class II alleles in the immune response to HCV and underscore the importance of studying genetic associations in an ethnically diverse cohort.

Comments

This article is in the public domain, and no copyright is claimed.

Additional Comments

National Institutes of Health grant #s: DA-00441, DA-04334, DA-13324 HD-43200, HD-4-3200, RR-06020, RR-00071, RR-00059, RR-02558; National Institutes of Health contract #s: CO-56000, CP-33002; Bureau of Maternal and Child Health and Resources Development grant #: MCJ-060570

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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