Biology Faculty Articles

Title

The Influence of HLA Genotype on AIDS

Document Type

Article

Publication Date

2-2003

Publication Title

Annual Review of Medicine

Keywords

HIV, AIDS immunity, Genetic epidemiology

ISSN

0066-4219

Volume

54

Issue/No.

1

First Page

535

Last Page

551

Abstract

Genetic resistance to infectious diseases is likely to involve a complex array of immune-response and other genes with variants that impose subtle but significant consequences on gene expression or protein function. We have gained considerable insight into the genetic determinants of HIV-1 disease, and the HLA class I genes appear to be highly influential in this regard. Numerous reports have identified a role for HLA genotype in AIDS outcomes, implicating many HLA alleles in various aspects of HIV disease. Here we review the HLA associations with progression to AIDS that have been consistently affirmed and discuss the underlying mechanisms behind some of these associations based on functional studies of immune cell recognition.

Comments

©2003 Annual Reviews

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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