Biology Faculty Articles

Title

Non-Hodgkin's B Cell Lymphoma in Persons with Acquired Immunodeficiency Syndrome is Associated with Increased Serum Levels of IL10, or the IL10 Promoter −592 C/C Genotype

Document Type

Article

Publication Date

11-2003

Publication Title

Clinical Immunology

Keywords

Interleukin-10, B cell, Lymphoma, AIDS, Serum, Predictor, Single-nucleotide polymorphism, Genotype, Haplotype, Cytokine

ISSN

1521-6616

Volume

109

Issue/No.

2

First Page

119

Last Page

129

Abstract

Interleukin-10 (IL10) may contribute to the development of non-Hodgkin's B cell lymphoma, especially in the context of acquired immunodeficiency syndrome (AIDS), where lymphoma incidence is greatly increased. Utilizing specimens from the Multicenter AIDS Cohort Study (MACS) obtained prior to diagnosis of AIDS-associated lymphoma, detectable serum human IL10 was seen much more frequently in lymphoma cases (n = 61, 26%) compared to CD4-matched AIDS controls (5%, P = 0.004), or to HIV-infected (2%, P = 0.002) or HIV uninfected subjects (0%, P = 0.0003). In longitudinal studies, detectable IL10 occurred at times closest to but preceding lymphoma diagnosis (P = 0.01). In an independent genetic analysis of single-nucleotide polymorphisms within the promoter region of the IL10 gene in 1157 MACS subjects, a high IL10-expressing genotype (−592 C/C) was overrepresented among lymphoma subjects (P = 0.009), even when controlling for race (P = 0.006). These results suggest that elevated serum IL10 or the IL10 promoter −592 C/C genotype are associated with development of AIDS lymphoma.

Comments

©2003 Elsevier Inc.

Additional Comments

National Institutes of Health grant #s: CA57152, CD73475, AI35040, CA96888; University wide AIDS Research Program grant #: CC99-LA-002; National Institute of Allergy and Infectious Diseases grant #s: U01-AI35042, 5-M01-RR00722 (GCRC), U01-A135043, U01-AI37984, U01-A135039, U01-AI35040, U01-AI37613, U01-AI35041; National Cancer Institute contract #: N01-CO56000

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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