Title

Non-Hodgkin's B Cell Lymphoma in Persons with Acquired Immunodeficiency Syndrome is Associated with Increased Serum Levels of IL10, or the IL10 Promoter −592 C/C Genotype

Authors

Elizabeth Crabb Breen, University of California - Los Angeles
W. John Boscardin, University of California - Los Angeles
Roger Detels, University of California - Los Angeles
Lisa Jacobson, Johns Hopkins School of Hygiene and Public Health
Michael W. Smith, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Joan S. Chmiel, Northwestern University
Charles Rinaldo, University of Pittsburgh
Shenghan Lai, Johns Hopkins School of Hygiene and Public Health
Otoniel Martinez-Maza, University of California - Los Angeles

Document Type

Article

Publication Date

11-2003

Publication Title

Clinical Immunology

Keywords

Interleukin-10, B cell, Lymphoma, AIDS, Serum, Predictor, Single-nucleotide polymorphism, Genotype, Haplotype, Cytokine

ISSN

1521-6616

Volume

109

Issue/No.

2

First Page

119

Last Page

129

Abstract

Interleukin-10 (IL10) may contribute to the development of non-Hodgkin's B cell lymphoma, especially in the context of acquired immunodeficiency syndrome (AIDS), where lymphoma incidence is greatly increased. Utilizing specimens from the Multicenter AIDS Cohort Study (MACS) obtained prior to diagnosis of AIDS-associated lymphoma, detectable serum human IL10 was seen much more frequently in lymphoma cases (n = 61, 26%) compared to CD4-matched AIDS controls (5%, P = 0.004), or to HIV-infected (2%, P = 0.002) or HIV uninfected subjects (0%, P = 0.0003). In longitudinal studies, detectable IL10 occurred at times closest to but preceding lymphoma diagnosis (P = 0.01). In an independent genetic analysis of single-nucleotide polymorphisms within the promoter region of the IL10 gene in 1157 MACS subjects, a high IL10-expressing genotype (−592 C/C) was overrepresented among lymphoma subjects (P = 0.009), even when controlling for race (P = 0.006). These results suggest that elevated serum IL10 or the IL10 promoter −592 C/C genotype are associated with development of AIDS lymphoma.

Comments

©2003 Elsevier Inc.

Additional Comments

National Institutes of Health grant #s: CA57152, CD73475, AI35040, CA96888; University wide AIDS Research Program grant #: CC99-LA-002; National Institute of Allergy and Infectious Diseases grant #s: U01-AI35042, 5-M01-RR00722 (GCRC), U01-A135043, U01-AI37984, U01-A135039, U01-AI35040, U01-AI37613, U01-AI35041; National Cancer Institute contract #: N01-CO56000

NSUWorks Citation

Crabb Breen, Elizabeth; W. John Boscardin; Roger Detels; Lisa Jacobson; Michael W. Smith; Stephen J. O'Brien; Joan S. Chmiel; Charles Rinaldo; Shenghan Lai; and Otoniel Martinez-Maza. 2003. "Non-Hodgkin's B Cell Lymphoma in Persons with Acquired Immunodeficiency Syndrome is Associated with Increased Serum Levels of IL10, or the IL10 Promoter −592 C/C Genotype." Clinical Immunology 109, (2): 119-129. https://nsuworks.nova.edu/cnso_bio_facarticles/595

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015