Biology Faculty Articles

Title

Lack of Associations Between HLA Class II Alleles and Resistance to HIV-1 Infection Among White, Non-Hispanic Homosexual Men

Document Type

Article

Publication Date

10-1-2004

Publication Title

Journal of Acquired Immune Deficiency Syndromes

Keywords

Resistance to HIV-1 infection, HLA, Class II

ISSN

1525-4135

Volume

37

Issue/No.

2

First Page

1313

Last Page

1317

Abstract

HLA class II alleles were molecularly typed for 100 high-risk seronegative men and 184 low-risk seroconverters from the Multicenter AIDS Cohort Study (MACS). Seven resistant individuals homozygous for CCR5Δ32 deletions were excluded from analysis. In the univariate analysis, no significant HLA class II associations with resistance/susceptibility to HIV type 1 infection were identified. However, the transporter associated with antigen presentation 2 (TAP2) Ala 665 variant associated with resistance in earlier analyses in the MACS was in linkage disequilibrium with some HLA class II alleles. After adjusting for the established associations with HLA-A*0205 subgroup and TAP2 Ala 665 variant, no HLA class II alleles were independently associated with resistance/susceptibility to HIV-1 infection. Other genetic factors in the HLA class II-TAP region of the major histocompatibility complex might be involved.

Comments

©2004 Lippincott Williams & Wilkins, Inc.

Additional Comments

National Cancer Institute contract #: NO1-CO-12400; National Institute of Allergy and Infectious Diseases contract #: R01-AI41951

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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