Biology Faculty Articles

Title

FIV Diversity: FIVPle Subtype Composition May Influence Disease Outcome in African Lions

Document Type

Article

Publication Date

10-15-2011

Publication Title

Veterinary Immunology and Immunopathology

Keywords

FIVPle, Lions, CDV, Babesia

ISSN

0165-2427

Volume

143

Issue/No.

3-4

First Page

338

Last Page

346

Abstract

Feline immunodeficiency virus (FIV) infects domestic cats and at least 20 additional species of non-domestic felids throughout the world. Strains specific to domestic cat (FIVFca) produce AIDS-like disease progression, sequelae and pathology providing an informative model for HIV infection in humans. Less is known about the immunological and pathological influence of FIV in other felid species although multiple distinct strains of FIV circulate in natural populations. As in HIV-1 and HIV-2, multiple diverse cross-species infections may have occurred. In the Serengeti National Park, Tanzania, three divergent subtypes of lion FIV (FIVPle) are endemic, whereby 100% of adult lions are infected with one or more of these strains. Herein, the relative distribution of these subtypes in the population are surveyed and, combined with observed differences in lion mortality due to secondary infections based on FIVPle subtypes, the data suggest that FIVPle subtypes may have different patterns of pathogenicity and transmissibility among wild lion populations.

Comments

© 2011 Elsevier B.V. All rights reserved.

Additional Comments

National Cancer Institute contract #: HHSN26120080001E

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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