Biology Faculty Articles

Title

Chromosomal Mapping of Lysosomal Enzyme Structural Genes in the Domestic Cat

Document Type

Article

Publication Date

5-1988

Publication Title

Genomics

ISSN

0888-7543

Volume

2

Issue/No.

4

First Page

329

Last Page

336

Abstract

A panel of 42 rodent × cat somatic cell hybrids has been used to assign seven structural genes for lysosomal enzymes to specific chromosomes in the domestic cat. The assignments include α-glucosidase (GANAB) to chromosome D1, α-galactosidase (GLA) to the X chromosome, β-galactosidase 1 (GLB1) to chromosome B3, β-glucuronidase (GUSB) to chromosome E3, α-mannosidase A (MANA) to chromosome B3, α-l-fucosidase (FUCA) to chromosome C1, and hexosaminidase A (HEXA) to chromosome B3. In all cases, the feline lysosomal enzyme genes were located in linkage groups which were syntenic with their homologous positions in the human gene map. These assignments expand the genetic map of the cat and reaffirm the extensive syntenic homology between the chromosome maps of man and cat.

Comments

© 1988 Published by Elsevier Inc.

Additional Comments

National Cancer Institute contract #: NO1-CO-74102

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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