Biology Faculty Articles
Title
Nanoparticles for Fidgety Cell Movement and Enhanced Wound Healing
Document Type
Article
Publication Date
9-2015
Publication Title
Journal of Investigative Dermatology
Keywords
Cell Motility, Wound Healing, Microtubules, Cell Mitigation, Dermatology
ISSN
0022-202X
Volume
135
Issue/No.
9
First Page
2151
Last Page
2153
Abstract
Complex spatiotemporal interaction of Rho GTPases with microtubules (MTs) and MT-associated proteins drives directed cellular migration. In this issue, Charafeddine et al. describe a role for a novel MT-severing enzyme, fidgetin-like 2 (FL2), in directional migration of keratinocytes and fibroblasts. FL2 normally localizes to the leading edge of the cell cortex where it shears MTs, thus dictating the size and distribution of focal adhesions by regulating cytoskeletal remodeling. Small interfering RNA (siRNA)-directed knockdown of FL2 increases cell migration and focal adhesion area in vitro through possible interaction with Rho GTPases. Efficient FL2 knockdown in murine wounds was achieved using nanoparticles as a siRNA delivery vehicle, and this resulted in enhanced wound closure in vivo. Effective siRNA nanoparticle targeting of MT-severing enzymes offers promise of controlled and targeted delivery that may maximize therapeutic success for patients with burn wounds and chronic wound disorders.
NSUWorks Citation
Jozic, Ivan; Sylvia Daunert; Marjana Tomic-Canic; and Irena Pastar. 2015. "Nanoparticles for Fidgety Cell Movement and Enhanced Wound Healing." Journal of Investigative Dermatology 135, (9): 2151-2153. https://nsuworks.nova.edu/cnso_bio_facarticles/13
Comments
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