Psychiatric and Neuropsychological Sequelae of Herpes Simplex Encephalitis

Authors

Carla F. Cabrera, Nova Southeastern UniversityFollow
Charles J. Golden, Nova Southeastern UniversityFollow

Abstract

Herpes simplex encephalitis (HSE) is caused by the herpes simplex virus (HSV), often from the Type 1 (HSV-1) viral infection. This neurotropic double-stranded DNA virus impairs the integrity and permeability of the blood-brain barrier, allowing the virus to enter the brain. In several studies, HSV-1 impacts the temporal lobe, frontal lobe, and limbic system, leading to brain damage. While significant progress has occurred in understanding this infection, clinicians should be vigilant for acute and chronic complications associated with HSE, such as autoimmune encephalitis, differential diagnoses, and psychological disorders. A growing body of literature focuses on the evidence of an association between HSE and neuropsychological effects discussed in this review. Current research limitations and future research directions are discussed to highlight the need for further research efforts to improve the understanding of the long-term sequelae caused by HSE.

Recommended Citation

Cabrera, Carla F. and Golden, Charles J. (2022) "Psychiatric and Neuropsychological Sequelae of Herpes Simplex Encephalitis," Archives of Assessment Psychology: Vol. 12, Article 2.
Available at: https://nsuworks.nova.edu/psyassessment/vol12/iss1/2