HCNSO Student Theses and Dissertations
Copyright Statement
All rights reserved. This publication is intended for use solely by faculty, students, and staff of Nova Southeastern University. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, now known or later developed, including but not limited to photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author or the publisher.
Defense Date
6-1980
Document Type
Thesis - NSU Access Only
Department
Oceanographic Center
First Advisor
Joel Warren
Second Advisor
Barbara B. Jacobs
Abstract
A group of interrelated studies from these laboratories have shown that various cell-mediated and humoral immune processes were altered in rodents exposed to prolonged hyperbaric oxygen. The study here reported is based upon these findings and was undertaken to determine whether hyperoxygenemia would suppress cell-mediated rejection of foreign tissues and acceptance of xenogeneic tumor transplants. A Fischer 344 rat lymphoma (NRL 1871) was implanted intraperitoneally into C57BL/6, DBA/2 and BALB/c mice. Implants produced fatal neoplasms in 13 of 43 C57BL/6 and 6 of 18 DBA/2 mice given daily HBO for 30· days starting one day after implantation. None of the 17 BALB/c recipients given the same regimen of oxygen developed tumors nor did 117 untreated, tumor recipients observed over a period of 60 to 100 days. The xenogeneic growths metastasized extensively even after cessation of HBO therapy. The histologic appearance of these growths was identical with that of the parent lymphoma and they could be transplanted back to Fischer 344 rats but not to normal or HBO treated mice syngeneic with the primary xenogeneic host.
NSUWorks Citation
Miriam Sacksteder Fanshaw. 1980. Transplantation of Xenogeneic Tumors in Oxygen Immunosuppressed Mice. Master's thesis. Nova Southeastern University. Retrieved from NSUWorks, Oceanographic Center. (375)
https://nsuworks.nova.edu/occ_stuetd/375.