Mathematics Faculty Articles

Title

Novel T cell driven approach leads to the identification of immunoprevalent antigens

Document Type

Article

Publication Date

5-7-2012

Publication Title

Procedia in Vaccinology

Keywords

Human CD4+ T cells, Immunization, Immunoprevalent antigens, Infection

ISSN

1877282X

Volume

6

First Page

14

Last Page

20

Abstract

The prevention and treatment of infectious diseases is highly dependent on the availability of reliable diagnostic tests and protective or therapeutic vaccines. There also exists an urgent need to develop reliable biomarkers to monitor treatment success and to predict disease progression from asymptomatic to symptomatic disease in several infectious diseases. The elucidation of the disease-relevant antigens that elicit the protective immune responses is critical and required for the development of diagnostics and treatments. Here we present a novel " T cell driven approach" that permits the direct identification of pathogen epitopes and protein antigens capable of triggering specific T cell responses upon immunization in humans. © 2012.

ORCID ID

0000-0002-8194-5502

DOI

10.1016/j.provac.2012.04.004

Peer Reviewed

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