A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries
ACS Combinatorial Science
combinatorial libraries, guanidine, harmonic mean, isokinetic ratios, piperazine, positional scanning library, sulfonamide
A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.
Giulianotti, Marc; Debevac, Ginamarie; Santos, Radleigh; Maida, Laura E.; Chen, Wenteng; Ou, Lili; Yu, Yongping; Dooley, Colette T.; and Houghten, Richard A., "A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries" (2012). Mathematics Faculty Articles. 225.