Mathematics Faculty Articles

Title

A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries

Document Type

Article

Publication Date

8-23-2012

Publication Title

ACS Combinatorial Science

Keywords

combinatorial libraries, guanidine, harmonic mean, isokinetic ratios, piperazine, positional scanning library, sulfonamide

ISSN

2156-8952

Volume

14

Issue/No.

9

First Page

503

Last Page

512

Abstract

A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.

Comments

Copyright © 2012 American Chemical Society

DOI

10.1021/co300060s

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Peer Reviewed

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