Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery
ACS Combinatorial Science
combinatorial libraries, drug discovery, harmonic mean model, mixture activity
The use of the harmonic mean model for predicting the activities of a given mixture and its constituents has not previously been explored in the context of combinatorial libraries and drug discovery. Herein, the analyses of historical data confirm the harmonic mean as an accurate predictor of mixture activity. The implications of these results are discussed.
Santos, Radleigh; Giulianotti, Marc; Dooley, Colette T.; Pinilla, Clemencia; Appel, Jon R.; and Houghten, Richard A., "Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery" (2011). Mathematics Faculty Articles. 224.