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Abstract

The complex process of regulating gene expression involves a large number of cis- and trans-acting components. The cis elements also referred to as cis regulatory elements (CREs) are highly conserved across species, and are often referred to as conserved domains mainly located in the promoters of genes. The trans acting sequences such as enhancers, moderators and insulators are also crucial in the regulation of gene expression. With an increased influx of genomic and transcriptomic data, study of differentially expressed genes (DEGs) is highly effective in understanding genes that are either up- or down- regulated in response to a given treatment or stress condition as compared to the controls. In this case, a key step in understanding gene regulation involves identification of CREs in promoters of differentially expressed genes (DEGs) and examine shared patterns among those genes. In this paper, we will discuss the use of probing promoter regions of DEGs for conserved domains and their use in regulation of gene expression.

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