Title

Thermal and pH Sensitive Multifunctional Polymer Nanoparticles for Cancer Imaging and Therapy.

ISBN or ISSN

2046-2069

Volume

4

Issue

34

Publication Date / Copyright Date

1-1-2014

First Page

17959

Last Page

17968

DOI Number

10.1039/C4RA01112K

Abstract

In this study, we prepared novel poly (Glycerol malate co-dodecanedioate) (PGMD) NPs containing an imaging/hyperthermia agent (IR820) and a chemotherapeutic agent (doxorubicin, DOX). The PGMD polymer was prepared by thermal condensation. IR820 and DOX loaded PGMD NPs were prepared using the single oil emulsion technique. The size of the NPs measured was around 150 nm. Drug loading efficiency of DOX and IR820 was around 4% and 8%, respectively. An acidic environment (pH=5.0) induced higher DOX release as compared to pH=7.4. DOX release was also enhanced by exposure to laser, which increased the temperature to 42°C. Cytotoxicity of the drug loaded NPs was comparable in MES-SA but was higher in Dx5 cells compared to free drug (p<0.05). The combination of hyperthermia and chemotherapy improved cytotoxicity in both cell lines. The NP formulation significantly improved the plasma half-life of IR820 in mice after tail vein injection.

Disciplines

Medicine and Health Sciences

Keywords

IR820; Chemotherapy; Hyperthermia; multi-functional nano-particles; poly (Glycerol Malate co-dodecanedioate) (PGMD)

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