Faculty Articles

Title

Delayed maturation of receptive field center/surround mechanisms in V2

ISBN or ISSN

1091-6490

Volume

102

Issue

16

Publication Date / Copyright Date

1-1-2005

First Page

5862

Last Page

5867

DOI Number

10.1073/pnas.0501815102

Abstract

Neurons in the adult visual cortex are capable of integrating signals over a large area that surrounds their classic receptive field (RF), and this ability of cortical neurons is thought to be intimately involved in perceptual binding. It is not known, however, at what age these long-range signal interactions emerge. Here, we report that qualitatively adult-like center/surround interactions are already present in the primary visual cortex as early as postnatal day 14 in macaque monkeys. However, the RF surrounds of visual area 2 (V2) neurons were largely absent until 4 weeks of age and, as late as 8 weeks of age, center/surround signal interactions in V2 neurons were immature. Our results suggest that the cortical circuits underlying the RF center/surround of individual neurons mature considerably later in V2 than in the primary visual cortex and give critical evidence for the hypothesis that the functional maturation of the primate visual brain proceeds in a hierarchical manner.

Disciplines

Optometry

Keywords

monkey, postnatal development, primary visual cortex, long-range signal interaction, cortical circuits

Peer Reviewed

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