Faculty Books and Book Chapters

Understanding and Managing Antineoplastic and Antiretroviral Therapy

Title

Understanding and Managing Antineoplastic and Antiretroviral Therapy

Edition

1

ISBN or ISSN

9780190493097

Location

New York, NY

Chapter

29

Publication Date / Copyright Date

2017

First Page

309

Last Page

317

Publisher

Oxford University Press

DOI Number

10.1093/med/9780190493097.003.0029

Abstract

The use of combination antiretroviral therapy in patients with malignancies is associated with improved HIV and cancer-related outcomes. Combining antiretroviral and antineoplastic therapy is often complicated by significant drug-drug interactions, drug-disease state monitoring interactions and overlapping toxicities. Definitive pharmacokinetic studies evaluating drug interactions between antineoplastics and antiretrovirals are uncommon and clinical judgment must often be used to determine the potential for significant interactions. Adjusting antiretroviral therapy in response to significant drug interactions or overlapping toxicities is often more feasible than modifying antineoplastic protocols.

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Keywords

antineoplastic therapy, antiretroviral therapy, pharmacology

Files

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