Faculty Articles

PubMed Identifier

28128928

Title

A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage

Publication Title

ACS Chemical Neuroscience

Volume

8

Issue

6

Publication Date / Copyright Date

6-21-2017

First Page

1262

Last Page

1278

Publisher

American Chemical Society

DOI Number

10.1021/acschemneuro.6b00399

Abstract

Bivalent ligands targeting putative melanocortin receptor dimers have been developed and characterized in vitro; however, studies of their functional in vivo effects have been limited. The current report compares the effects of homobivalent ligand CJL-1-87, Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Keywords

Animals, Eating, Energy Metabolism, HEK293 Cells, Humans, Ligands, Mice, Oligopeptides, Receptors, Melanocortin

Peer Reviewed

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