Apolipoprotein-E (APO-E) genotype and symptoms of psychosis in Alzheimer's disease.
ISBN or ISSN
American journal of geriatric psychiatry
Publication Date / Copyright Date
The authors examined the association of Apolipoprotein-E (APO-E) genotype to symptoms of psychosis and depression in 501 patients diagnosed with probable (n=343) or possible (n=158) Alzheimer's disease (AD) according to NINCDS-ADRDA criteria. They observed the following APO-E genotypes: epsilon2/epsilon3 (n=19); epsilon2/epsilon4 (n=14); epsilon3/epsilon3 (n=228); epsilon3/epsilon4 (n=203); epsilon4/epsilon4 (n=37). In contrast to previous reports, the results did not indicate a relationship between either the epsilon4 allele or the epsilon2 allele and symptoms of mood disturbance in AD. However, an elevated risk for psychosis was shown, specifically, at the severe stage of cognitive impairment, among AD patients carrying the epsilon4 allele, after effects of age, gender, education, and level of cognitive impairment were controlled.
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
Age Factors, Aged, Alleles, Alzheimer Disease, Apolipoproteins E, Cognition Disorders, Depression, Educational Status, Female, Follow-Up Studies, Genotype, Humans, Male, Neuropsychological Tests, Psychotic Disorders, Risk Factors, Severity of Illness Index, Sex Factors
Harwood, Dylan G.; Barker, Warren W.; Ownby, Raymond L.; St George-Hyslop, P; and Duara, Ranjan, "Apolipoprotein-E (APO-E) genotype and symptoms of psychosis in Alzheimer's disease." (1999). College of Osteopathic Medicine Faculty Articles. 53.