Faculty Articles
Title
Apolipoprotein-E (APO-E) genotype and symptoms of psychosis in Alzheimer's disease.
ISBN or ISSN
1064-7481
Publication Title
American journal of geriatric psychiatry
Volume
7
Issue
2
Publication Date / Copyright Date
1-1-1999
First Page
119
Last Page
123
Abstract
The authors examined the association of Apolipoprotein-E (APO-E) genotype to symptoms of psychosis and depression in 501 patients diagnosed with probable (n=343) or possible (n=158) Alzheimer's disease (AD) according to NINCDS-ADRDA criteria. They observed the following APO-E genotypes: epsilon2/epsilon3 (n=19); epsilon2/epsilon4 (n=14); epsilon3/epsilon3 (n=228); epsilon3/epsilon4 (n=203); epsilon4/epsilon4 (n=37). In contrast to previous reports, the results did not indicate a relationship between either the epsilon4 allele or the epsilon2 allele and symptoms of mood disturbance in AD. However, an elevated risk for psychosis was shown, specifically, at the severe stage of cognitive impairment, among AD patients carrying the epsilon4 allele, after effects of age, gender, education, and level of cognitive impairment were controlled.
Disciplines
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
Keywords
Age Factors, Aged, Alleles, Alzheimer Disease, Apolipoproteins E, Cognition Disorders, Depression, Educational Status, Female, Follow-Up Studies, Genotype, Humans, Male, Neuropsychological Tests, Psychotic Disorders, Risk Factors, Severity of Illness Index, Sex Factors
NSUWorks Citation
Harwood, Dylan G.; Barker, Warren W.; Ownby, Raymond L.; St George-Hyslop, P; and Duara, Ranjan, "Apolipoprotein-E (APO-E) genotype and symptoms of psychosis in Alzheimer's disease." (1999). Faculty Articles. 53.
https://nsuworks.nova.edu/hpd_com_faculty_articles/53
