Immunologic status correlates with severity of physical symptoms and perceived illness burden in chronic fatigue syndrome patients
ISBN or ISSN
Journal of Chronic Fatigue Syndrome
Publication Date / Copyright Date
An open labeled, phase 1, safety and feasibility study using lymph node extraction, ex vivo lymph node cell expansion, followed by autologous cell reinfusion was evaluated as a potential immunomodulatory treatment strategy in patients with chronic fatigue syndrome (CFS). The experimental therapy utilized the cells of the lymph node, activated and grown in culture with defined media, interleukin-2 (IL-2) and anti-CD3 to activate and enhance cellular immunological functions. This procedure was designed to change the cytokine pattern of the lymph node lymphocytes to favor expression of T-helper (Th)l-type over Th2-type cytokines. The mixed population of ex vivo immune-enhanced cells were reinfused into the donor, who was carefully monitored for adverse events and possible clinical benefit. There were no adverse events. There were significant improvements in clinical status in association with a significant decrease in Th2-type cytokine production.
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
Cruess, S. E.; Klimas, Nancy G.; Antoni, M. H.; Helder, L.; Maher, K.; Keller, R.; and Fletcher, Mary A., "Immunologic status correlates with severity of physical symptoms and perceived illness burden in chronic fatigue syndrome patients" (2000). College of Osteopathic Medicine Faculty Articles. 465.