Faculty Articles
Title
Foamy virus infection in primates.
ISBN or ISSN
0047-2565
Publication Title
Journal of Medical Primatology
Volume
35
Issue
4-5
Publication Date / Copyright Date
8-1-2006
First Page
225
Last Page
235
Publisher
Wiley-Blackwell Publishing, Inc.
DOI Number
10.1111/j.1600-0684.2006.00171.x
Abstract
Foamy viruses (FV), the oldest known genus of Retroviridae, are unique among the retroviruses in having no disease association. It is not known why FV are non-pathogenic while infection by their closest relatives can be deadly. This may be related to the estimated 60 million years of coevolution of FV and their primate hosts. We review the current state of knowledge of FV infection, including information about the sites of viral replication and host immune responses, and discuss the role these may play in establishing persistent yet non-pathogenic infections. Whether FV has pathologic consequences in immunosuppressed hosts has not been thoroughly investigated. As most primates in HIV/SIV research are coinfected with FV, investigation into possible interactions between these viruses is of interest. The use of FV as a vector for gene therapy is also discussed.
Disciplines
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
Keywords
Animals, Evolution, Molecular, Humans, Immunity, Innate, Primates, Retroviridae Infections, Spumavirus, Virus Replication
NSUWorks Citation
Murray, Shannon Marie and Linial, M L, "Foamy virus infection in primates." (2006). Faculty Articles. 1549.
https://nsuworks.nova.edu/hpd_com_faculty_articles/1549