Faculty Articles

PubMed Identifier

2890215

Title

Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

ISBN or ISSN

0740-7750

Publication Title

Somatic cell and molecular genetics

Volume

13

Issue

6

Publication Date / Copyright Date

11-1987

First Page

671

Last Page

678

Abstract

The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.

Disciplines

Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy | Public Health

Keywords

Animals, Chromosome Mapping, DNA, Disease Models, Animal, Genetic Linkage, Humans, Mice, Muscular Dystrophy, Animal, Mutation, Nucleic Acid Hybridization, Polymorphism, Restriction Fragment Length, Species Specificity, X Chromosome

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