Observing the Impacts of Different Diets on Clinical Outcomes in patients with Alzheimer's disease: A Scoping Review
Speaker Credentials
OMS-III
Speaker Credentials
BS
College
Dr. Kiran C. Patel College of Osteopathic Medicine, DO
Medical Specialty
Neurology
Format
Poster
Start Date
November 2024
End Date
November 2024
Track
1
Abstract
Observing the Impacts of Different Diets on Clinical Outcomes in patients with Alzheimer's disease: A Scoping Review Authors: Quinn Jackson, OMS-III; Rachel Fricker,OMS-III; Erjola Toska, OMS-III; Alessandra Ottley,OMS-III; Alexa Carleo,OMS-III; Gabriella Cutrali, OMS-III; Olivia D’Alessio, OMS-III; Raquel Rossman, OMS-III; Samuel Kruchakov, OMS-III; Abraham Edelstein,OMS-III; Lubov Nathanson, Ph.D. Program: Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Florida Objectives: This study aimed to assess the literature published from 2013 to 2023 on the impact of diet on Alzheimer’s Disease (AD). Background: AD is primarily marked by β-amyloid plaques and neurofibrillary tangles, which impair neuronal synapses, leading to memory and cognitive decline. Tau proteins contribute to neurofibrillary tangles, worsening AD pathology. Nutrition can influence neuro-inflammatory pathways, and diets like ketogenic, Mediterranean, DASH, and plant-based have shown potential for preventing AD. Methods: A scoping review following PRISMA guidelines was conducted to gather evidence on diet and AD. Databases searched included EMBASE, MEDLINE, and Web of Science using terms such as “Alzheimer’s” and “ketogenic,” “DASH,” or “Mediterranean diet.” The search was limited to U.S.-published, English-language articles from January 2013 to September 2023. From an initial pool of 121 articles, 12 were selected for analysis following critical appraisal. Results: The final 12 studies were conducted in the U.S., Germany, and Spain, with sample sizes ranging from 20 to over 100 participants. Study types included longitudinal, cross-sectional, and intervention designs. Key findings highlighted the positive effects of Mediterranean, Ketogenic, DASH, and MIND diets on AD, though limitations such as small sample sizes and short study durations were noted. Conclusions: The Mediterranean Diet showed the strongest evidence for improving outcomes in AD patients. Other diets, such as DASH and MIND, also show promise, but more research is needed to establish definitive dietary recommendations for AD.
Observing the Impacts of Different Diets on Clinical Outcomes in patients with Alzheimer's disease: A Scoping Review
Observing the Impacts of Different Diets on Clinical Outcomes in patients with Alzheimer's disease: A Scoping Review Authors: Quinn Jackson, OMS-III; Rachel Fricker,OMS-III; Erjola Toska, OMS-III; Alessandra Ottley,OMS-III; Alexa Carleo,OMS-III; Gabriella Cutrali, OMS-III; Olivia D’Alessio, OMS-III; Raquel Rossman, OMS-III; Samuel Kruchakov, OMS-III; Abraham Edelstein,OMS-III; Lubov Nathanson, Ph.D. Program: Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Florida Objectives: This study aimed to assess the literature published from 2013 to 2023 on the impact of diet on Alzheimer’s Disease (AD). Background: AD is primarily marked by β-amyloid plaques and neurofibrillary tangles, which impair neuronal synapses, leading to memory and cognitive decline. Tau proteins contribute to neurofibrillary tangles, worsening AD pathology. Nutrition can influence neuro-inflammatory pathways, and diets like ketogenic, Mediterranean, DASH, and plant-based have shown potential for preventing AD. Methods: A scoping review following PRISMA guidelines was conducted to gather evidence on diet and AD. Databases searched included EMBASE, MEDLINE, and Web of Science using terms such as “Alzheimer’s” and “ketogenic,” “DASH,” or “Mediterranean diet.” The search was limited to U.S.-published, English-language articles from January 2013 to September 2023. From an initial pool of 121 articles, 12 were selected for analysis following critical appraisal. Results: The final 12 studies were conducted in the U.S., Germany, and Spain, with sample sizes ranging from 20 to over 100 participants. Study types included longitudinal, cross-sectional, and intervention designs. Key findings highlighted the positive effects of Mediterranean, Ketogenic, DASH, and MIND diets on AD, though limitations such as small sample sizes and short study durations were noted. Conclusions: The Mediterranean Diet showed the strongest evidence for improving outcomes in AD patients. Other diets, such as DASH and MIND, also show promise, but more research is needed to establish definitive dietary recommendations for AD.