Works

An opinion on the impacts of COVID-19 worldwide, Robert C. Speth
Robert Speth

Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer, Danial Mehranfard, Gabriela Perez, Andres Rodriguez, Julia M. Ladna, Christopher T. Neagra, Benjamin Goldstein, Timothy Carroll, Alice Tran, Malav Trivedi, Robert C. Speth
Robert Speth

Adenoviral and adeno-associated viral vectors-mediated neuronal gene transfer to cardiovascular control regions of the rat brain, Yanling Zhang, Yongxin Gao, Robert C. Speth, Nan Jiang, Yingying Mao, Colin Sumners, Hongwei Li
Robert Speth

Acute repeated intracerebroventricular injections of angiotensin II reduce agonist and antagonist radioligand binding in the paraventricular nucleus of the hypothalamus and median preoptic nucleus in the rat brain, Robert C. Speth, Peter J. Vento, Eduardo J. Carrera, Luz Gonzalez-Reily, Andrea Linares, Kira Santos, Jamala D. Swindle, Derek Daniels
Robert Speth

Angiotensin II increases intracellular calcium concentration in pig endometrial stromal cells through type 1 angiotensin receptors, but does not stimulate phospholipase C activity or prostaglandin F2alpha secretion, Steven M. Simasko, Gheorghe T. Braileanu, Robert C. Speth, Mark A. Mirando, Daisy Daubert, Jianbo Hu
Robert Speth

AT₁ angiotensin II receptor and novel non-AT₁, non-AT₂ angiotensin II/III binding site in brainstem cardiovascular regulatory centers of the spontaneously hypertensive rat, Erick A. Bourassa, Xiefan Fang, Xia Li, Alan F. Sved, Robert C. Speth
Robert Speth

Alterations in GHRH binding and GHRH receptor mRNA in the pituitary of adult dw/dw rats, János Gardi, Robert C. Speth, Ping Taishi, Bálint Kacsóh, Ferenc Obál, James M. Krueger
Robert Speth

Angiotensin II administration to COVID-19 patients is not advisable, Robert C. Speth
Robert Speth

ANG II AT(1) and AT(2) receptors in developing kidney of normal microswine, Susan P. Bagby, Linda S. LeBard, Zaiming Luo, Bryan E. Ogden, Christopher Corless, Elizabeth D. McPherson, Robert C. Speth
Robert Speth

A life well-lived: Henry I. "Hank" Yamamura, Robert C. Speth
Robert Speth

Brain AT1 angiotensin receptor subtype binding: importance of peptidase inhibition for identification of angiotensin II as its endogenous ligand, Vardan T. Karamyan, Rama Gadepalli, John M. Rimoldi, Robert C. Speth
Robert Speth

Animal models of BMAA neurotoxicity: a critical review, Vardan T. Karamyan, Robert C. Speth
Robert Speth

Angiotensin type 1 receptor resistance to blockade in the opossum proximal tubule cell due to variations in the binding pocket, Ravi Nistala, Bradley T. Andresen, Lakshmi Pulakat, Alex Meuth, Catherine Sinak, Chirag Mandavia, Thomas Thekkumkara, Robert C. Speth, Adam Whaley-Connell, James R. Sowers
Robert Speth

Angiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension, Beverly L. Falcón, Jillian M. Stewart, Erick Bourassa, Michael J. Katovich, Glenn Walter, Robert C. Speth, Colin Sumners, Mohan K. Raizada
Robert Speth

Atypical signaling and functional desensitization response of MAS receptor to peptide ligands, Kalyan C. Tirupula, Russell Desnoyer, Robert C. Speth, Sadashiva S. Karnik
Robert Speth

Basomedial hypothalamic injections of neuropeptide Y conjugated to saporin selectively disrupt hypothalamic controls of food intake, Kishor Bugarith, Thu T. Dinh, Ai-Jun Li, Robert C. Speth, Sue Ritter
Robert Speth

Anteroposterior distribution of AT(1) angiotensin receptors in caudal brainstem cardiovascular regulatory centers of the rat, Erick A. Bourassa, Alan F. Sved, Robert C. Speth
Robert Speth

Angiotensin II receptor subtype distribution in the rabbit brain, Sabyasachi Moulik, Robert C. Speth, Barbara B. Turner, Brian P. Rowe
Robert Speth

Angiotensin modulation of rostral ventrolateral medulla (RVLM) in cardiovascular regulation, Erick A. Bourassa, Alan F. Sved, Robert C. Speth
Robert Speth

Angiotensin II type 1 and 2 receptors in conduit arteries of normal developing microswine, Susan P. Bagby, Linda S. LeBard, Zaiming Luo, Robert C. Speth, Bryan E. Ogden, Christopher L. Corless
Robert Speth

Chymase-like angiotensin II-generating activity in end-stage human autosomal dominant polycystic kidney disease, Elizabeth A. McPherson, Zaiming Luo, Rachel A. Brown, Linda S. LeBard, Christopher C. Corless, Robert C. Speth, Susan P. Bagby
Robert Speth

Chronic administration of pharmacological doses of angiotensin 1-7 and iodoangiotensin 1-7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats, Filipe F. Stoyell-Conti, Alesa Chabbra, Joseph Puthentharayil, Katya Rigatto, Robert C. Speth
Robert Speth

Commentary on: "Does COVID19 Infect the Brain? If So, Smokers Might Be at a Higher Risk", Robert C. Speth
Robert Speth

Central pressor actions of aminopeptidase-resistant angiotensin II analogs: challenging the angiotensin III hypothesis, Ranjita J. Kokje, Wendy L. Wilson, Travis E. Brown, Vardan T. Karamyan, John W. Wright, Robert C. Speth
Robert Speth

Comparative evaluation of biased agonists Sarcosine , d-Alanine -Angiotensin (Ang) II (SD Ang II) and Sarcosine , Isoleucine -Ang II (SI Ang II) and their radioiodinated congeners binding to rat liver membrane AT receptors, Natalia M. Noto, Yazmin M. Restrepo, Hong W. Pang, Filipe Stoyell-Conti, Crystal A. West, Robert C. Speth, Nova Southeastern University
Robert Speth

Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats, John W. Wright, Elizabeth Tamura-Myers, Wendy L. Wilson, Bernard P. Roques, Catherine Llorens-Cortes, Robert C. Speth, Joseph W. Harding
Robert Speth

Characterization of the brain-specific non-AT(1), non-AT(2) angiotensin binding site in the mouse, Vardan T. Karamyan, Florian Gembardt, Felicia M. Rabey, Thomas Walther, Robert C. Speth
Robert Speth

Cholinergic anti-inflammatory pathway and COVID-19, Danial Mehranfard, Robert C. Speth
Robert Speth

Cannabinoid ester constituents from high-potency Cannabis sativa, Safwat A. Ahmed, Samir A. Ross, Desmond Slade, Mohamed M. Radwan, Fazila Zulfiqar, Rae R. Matsumoto, Yan-Tong Xu, Eddy Viard, Robert C. Speth, Vardan T. Karamyan, M A. ElSohly
Robert Speth

Brain RAS: Hypertension and Beyond, Marc de Gasparo, Robert C. Speth, Ovidiu C. Baltatu, Patrick Vanderheyden
Robert Speth

CGP42112: the full AT2 receptor agonist and its role in the renin-angiotensin-aldosterone system: no longer misunderstood, Yazmin M. Restrepo, Natalia M. Noto, Robert C. Speth
Robert Speth

Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension, Yumei Feng, Huijing Xia, Yanhui Cai, Carmen M. Halabi, Lenice K. Becker, Robson A. Santos, Robert C. Speth, Curt D. Sigmund, Eric Lazartigues
Robert Speth

Brain angiotensinergic activity: the state of our current knowledge, Robert C. Speth, Travis E. Brown, Ryan D. Barnes, John W. Wright
Robert Speth

Brain angiotensinergic mediation of enhanced water consumption in lactating rats, Robert C. Speth, M Susan Smith, Kevin L. Grove
Robert Speth

Brain angiotensin receptors and binding proteins, Robert C. Speth, Vardan T. Karamyan
Robert Speth

Ignore lies about animal research, Robert C. Speth
Robert Speth

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists, Zoe M. Koerperich, Mark D. Ericson, Katie T. Freeman, Robert C. Speth, Irina D. Pogozheva, Henry I. Mosberg, Carrie Haskell-Luevano
Robert Speth

Identification of a novel non-AT1, non-AT2 angiotensin binding site in the rat brain, Vardan T. Karamyan, Robert C. Speth
Robert Speth

Identification of membrane-bound variant of metalloendopeptidase neurolysin (EC 3.4.24.16) as the non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site, Naomi J. Wangler, Kira L. Santos, Ines Schadock, Fred K. Hagen, Emanuel Escher, Michael Bader, Robert C. Speth, Vardan T. Karamyan
Robert Speth

I-Angiotensin 1-7 binds to a different site than angiotensin 1-7 in tissue membrane preparations, Filipe F. Stoyell-Conti, Sarin Itty, Christy Abraham, Katya Rigatto, Crystal A. West, Robert C. Speth
Robert Speth

Human brain contains a novel non-AT1, non-AT2 binding site for active angiotensin peptides, Vardan T. Karamyan, Craig A. Stockmeier, Robert C. Speth
Robert Speth

Homologous and lysophosphatidic acid-induced desensitization of the atrial natriuretic peptide receptor, guanylyl cyclase-A, in MA-10 leydig cells, Dieter Müller, Lourdes Cortes-Dericks, Lygia T. Budnik, Bärbel Brunswig-Spickenheier, Maria Pancratius, Robert C. Speth, Amal K. Mukhopadhyay, Ralf Middendorff
Robert Speth

Expression of guanylyl cyclase (GC)-A and GC-B during brain development: evidence for a role of GC-B in perinatal neurogenesis, Dieter Müller, Balanes Hida, Gabriela Guidone, Robert C. Speth, Tatyana V. Michurina, Grigori Enikolopov, Ralf Middendorff
Robert Speth

Hippocampal versus cortical deletion of cholinergic receptor muscarinic 1 in mice differentially affects post-translational modifications and supramolecular assembly of respiratory chain-associated proteins, mitochondrial ultrastructure, and respiration: implications in Alzheimer's disease, Mohammad Golam Sabbir, Mamiko Swanson, Robert C. Speth, Benedict C. Albensi
Robert Speth

Educational initiative in an NCATS TL1 training program to address the impact of systemic racism on human health, biomedical research, and the translational scientist, Martha D. Gay, Kimberly A. Bell, Emily A. Bujold, Marilla Geraci, Dexter L. Lee, Kathryn Sandberg, Robert C. Speth
Robert Speth

Enzymatic pathways of the brain renin-angiotensin system: unsolved problems and continuing challenges, Vardan T. Karamyan, Robert C. Speth
Robert Speth

Distribution of a novel binding site for angiotensins II and III in mouse tissues, Felicia M. Rabey, Vardan T. Karamyan, Robert C. Speth
Robert Speth

Effect of a perinatal high-salt diet on blood pressure control mechanisms in young Sprague-Dawley rats, Steven J. Swenson, Robert C. Speth, James P. Porter
Robert Speth

Distribution of the non-AT1, non-AT2 angiotensin-binding site in the rat brain: preliminary characterization, Vardan T. Karamyan, Robert C. Speth
Robert Speth

Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1, isoleucine8 angiotensin II in neurolysin knockout mouse brains, Robert C. Speth, Eduardo J. Carrera, Catalina Bretón, Andrea Linares, Luz Gonzalez-Reiley, Jamala D. Swindle, Kira L. Santos, Ines Schadock, Michael Bader, Vardan T. Karamyan
Robert Speth

Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome, Cassia S. Mizuno, Amar G. Chittiboyina, Falgun H. Shah, Akshay Patny, Theodore W. Kurtz, Harrihar A. Pershadsingh, Robert C. Speth, Vardan T. Karamyan, Paulo B. Carvalho, Mitchell A. Avery
Robert Speth

Countering the classical renin-angiotensin system, Natalia M. Noto, Yazmin M. Restrepo, Robert C. Speth
Robert Speth

Phospholipase C inhibitor U73122 attenuates the dipsogenic response induced by angiotensin II, Travis E. Brown, John W. Wright, Robert C. Speth
Robert Speth

Neuronal differentiation of NG108-15 cells has impact on nitric oxide- and membrane (natriuretic peptide receptor-A) cyclic GMP-generating proteins, Dieter Müller, Karen J. Greenland, Robert C. Speth, Ralf Middendorff
Robert Speth

Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7), Justin L. Grobe, Adam P. Mecca, Melissa Lingis, Vinayak Shenoy, Tonya A. Bolton, Juline M. Machado, Robert C. Speth, Mohan K. Raizada, Michael J. Katovich
Robert Speth

Preliminary biochemical characterization of the novel, non-AT1, non-AT2 angiotensin binding site from the rat brain, Vardan T. Karamyan, Jason Arsenault, Emanuel Escher, Robert C. Speth
Robert Speth

Placental insufficiency results in temporal alterations in the renin angiotensin system in male hypertensive growth restricted offspring, Daniela Grigore, Norma B. Ojeda, Elliot B. Robertson, Antoinette S. Dawson, Contrina A. Huffman, Erick A. Bourassa, Robert C. Speth, K Bridget Brosnihan, Barbara T. Alexander
Robert Speth

Pharmacological characterization of a novel non-AT1, non-AT2 angiotensin binding site identified as neurolysin, Jamala D. Swindle, Kira L. Santos, Robert C. Speth
Robert Speth

Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice, Kavaljit H. Chhabra, Huijing Xia, Kim Brint Pedersen, Robert C. Speth, Eric Lazartigues
Robert Speth

Preliminary study of ovariectomy and chronic losartan-induced alterations in brain AT receptors, Danial Mehranfard, Andrea Linares, Alesa Chabbra, Glenda Campos, Aline M. de Souza, Hong Ji, Crystal West, Kathryn Sandberg, Robert C. Speth
Robert Speth

Nanoparticle approaches for the renin-angiotensin system, Sajini D. Hettiarachchi, Young M. Kwon, Yadollah Omidi, Robert C. Speth
Robert Speth

Immunohistochemical Localization of AT1a, AT1b, and AT2 Angiotensin II Receptor Subtypes in the Rat Adrenal, Pituitary, and Brain with a Perspective Commentary, Courtney Premer, Courtney Lamondin, Ann Mitzey, Robert C. Speth, Mark S. Brownfield
Robert Speth

NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius, Gang Wang, Josef Anrather, Jie Huang, Robert C. Speth, Virginia M. Pickel, Costantino Iadecola
Robert Speth

Modulation of the rat angiotensin type 1a receptor by an upstream short open reading frame, Parnika S. Kadam, Susette C. Mueller, Hong Ji, Jun Liu, Amrita V. Pai, Junfeng Ma, Robert C. Speth, Kathryn Sandberg
Robert Speth

Morphometric analysis of the uterine endometrium of swine on days 12 and 16 postestrus, Dianna M. Blackwell, Robert C. Speth, Mark A. Mirando
Robert Speth

Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) Protein in the Hippocampus and Temporal Cortex of a Subset of Individuals with Alzheimer's Disease, Parkinson's Disease, or Frontotemporal Dementia: Implications for Patient Survival, Mohammad Golam Sabbir, Robert C. Speth, Benedict C. Albensi
Robert Speth

Metabolism of angiotensin peptides by angiotensin converting enzyme 2 (ACE2) and analysis of the effect of excess zinc on ACE2 enzymatic activity, Yasmin Polak, Robert C. Speth
Robert Speth

Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19, Branka Miličić Stanić, Sydney Maddox, Aline M. de Souza, Xie Wu, Danial Mehranfard, Hong Ji, Robert C. Speth, Kathryn Sandberg
Robert Speth

Increased expression of angiotensin II type 2 receptors in the solitary-vagal complex blunts renovascular hypertension, Graziela Torres Blanch, André Henrique Freiria-Oliveira, Guilherme Fleury Speretta, Eduardo J. Carrera, Hongwei Li, Robert C. Speth, Eduardo Colombari, Colin Sumners, Débora S. Colombari
Robert Speth

Keep taking your ACE inhibitors and ARBs during the COVID 19 pandemic, Robert C. Speth
Robert Speth

The possible role of a bacterial aspartate β-decarboxylase in the biosynthesis of alamandine, Shalinee Jha, Robert C. Speth, Peter Macheroux
Robert Speth

The effects of para-chloromercuribenzoic acid and different oxidative and sulfhydryl agents on a novel, non-AT1, non-AT2 angiotensin binding site identified as neurolysin, Kira L. Santos, Megan A. Vento, John W. Wright, Robert C. Speth
Robert Speth

The FDA Funding Crisis, Judith Alphonse, Sireesha Bellam, Marlene Fernandez, Anishka Gilbert, Lauren Roper, Antonia Zapantis, Robert C. Speth
Robert Speth

Spatiotemporal regulation of the two atrial natriuretic peptide receptors in testis, Dieter Müller, Amal K. Mukhopadhyay, Robert C. Speth, Gabriela Guidone, Regine Potthast, Lincoln R. Potter, Ralf Middendorff
Robert Speth

Sex-Specific Modulation of Blood Pressure and the Renin-Angiotensin System by ACE (Angiotensin-Converting Enzyme) 2, Hong Ji, Aline M. de Souza, Bilkish Bajaj, Wei Zheng, Xie Wu, Robert C. Speth, Kathryn Sandberg
Robert Speth

Sex-specific T-cell regulation of angiotensin II-dependent hypertension, Hong Ji, Wei Zheng, Xiangjun Li, Jun Liu, Xie Wu, Monan Angela Zhang, Jason G. Umans, Meredith Hay, Robert C. Speth, Shannon E. Dunn, Kathryn Sandberg
Robert Speth

Sex differences in angiotensin signaling in bulbospinal neurons in the rat rostral ventrolateral medulla, Gang Wang, Teresa A. Milner, Robert C. Speth, Andrea C. Gore, Di Wu, Costantino Iadecola, Joseph P. Pierce
Robert Speth

Serotonin rising, Robert C. Speth
Robert Speth

Selective inhibition of angiotensin receptor signaling through Erk1/2 pathway by a novel peptide, Jun Liu, Gina L. Yosten, Hong Ji, Dan Zhang, Wei Zheng, Robert C. Speth, Willis K. Samson, Kathryn Sandberg
Robert Speth

Roles of brain angiotensins II and III in thirst and sodium appetite, Wendy L. Wilson, Bernard P. Roques, Catherine Llorens-Cortes, Robert C. Speth, Joseph W. Harding, John W. Wright
Robert Speth

Severe food restriction activates the central renin angiotensin system, Aline Maria De Souza, Andrea Linares, Robert C. Speth, Glenda V. Campos, Hong Ji, Deoclécio Chianca, Kathryn Sandberg, Rodrigo C. De Menezes
Robert Speth

Response to recent commentaries regarding the involvement of angiotensin-converting enzyme 2 (ACE2) and renin-angiotensin system blockers in SARS-CoV-2 infections, Robert C. Speth
Robert Speth

Renin-Angiotensin System Inhibition in Advanced CKD, Robert C. Speth
Robert Speth

Sarcosine1,glycine8 angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist, Robert C. Speth
Robert Speth

The significance of brain aminopeptidases in the regulation of the actions of angiotensin peptides in the brain, Robert C. Speth, Vardan T. Karamyan
Robert Speth

The role of the brain renin-angiotensin system (RAS) in mild traumatic brain injury (TBI), Jason D. Vadhan, Robert C. Speth
Robert Speth

Use of positron emission tomography to study AT1 receptor regulation in vivo, Zsolt Szabo, Robert C. Speth, P Randy Brown, Levente Kerenyi, Pan Fu Kao, William B. Mathews, Hayden T. Ravert, John Hilton, Paige Rauseo, Robert F. Dannals, Wei Zheng, Sunghou Lee, Kathryn Sandberg
Robert Speth

The ocular renin-angiotensin system: a therapeutic target for the treatment of ocular disease, Michael J. Giese, Robert C. Speth
Robert Speth

Why Angiotensin II is a Poor Choice for Circulatory Support of Ventilated COVID-19 Patients Compared to Vasopressin, Robert C. Speth, Michael Bader
Robert Speth

Water deprivation increases angiotensin-converting enzyme but not AT(1) receptor expression in brainstem and paraventricular nucleus of the hypothalamus of the rat, Erick A. Bourassa, Robert C. Speth
Robert Speth

Nanoparticle approaches for the renin-angiotensin system, Sajini D. Hettiarachchi, Young M. Kwon, Yadollah Omidi, Robert C. Speth
HPD Articles

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Renin-Angiotensin System Inhibition in Advanced CKD, Robert C. Speth
HPD Articles