The therapeutic potential of targeting cardiac RGS4., Giselle Del Calvo, Teresa Baggio Lopez, Anastasios Lymperopoulos
HPD Articles

Clinical pharmacology of cardiac cyclic AMP in human heart failure: too much or too little?, Anastasios Lymperopoulos
HPD Articles

Editorial to the IJMS Special Issue on Sglt2 Inhibitors Vol. 1, Anastasios Lymperopoulos
HPD Articles

Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4., Jordana I. Borges, Malka S. Suster, Anastasios Lymperopoulos
HPD Articles

Angiotensin receptor blocker drugs and inhibition of adrenal beta-arrestin-1-dependent aldosterone production: Implications for heart failure therapy., Anastasios Lymperopoulos, Beatrix Aukszi
Beatrix Aukszi

Osteopontin & β2-adrenergic receptor signaling in cardiac fibrosis, Celina M. Pollard, Arianna Perez, Natalie Cora, Krysten E. Ferraino, Janelle M. Pereyra, Jennifer Ghandour, Eliany Garcia, Rachel Valiente, Shelby L. Wertz, Lina A. Shehadeh, Anastasios Lymperopoulos
Health Professions Division REACH Day

Cardiac Betaarrestin2 Promotes Contractility by Enhancing SERCA2a SUMOylation and Activity, Anastasios Lymperopoulos, Malika Jafferjee, T. Reyes Valero, C. Marrero, Katie Anne McCrink, Ava Brill, E. Gao, W. J. Koch
Faculty Proceedings, Presentations, Posters, Speeches, Lectures, etc.

Differential Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Suggest GRK5-Mediated Cardio-protection Against Mineralocorticoids, Anastasios Lymperopoulos, Katie Anne McCrink, Ava Brill, Jennifer Maning, Victoria Desimine, Beatrix Aukszi
Faculty Proceedings, Presentations, Posters, Speeches, Lectures, etc.

Differential Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Suggest GRK5-Mediated Cardio-protection Against Mineralocorticoids, Anastasios Lymperopoulos
Faculty Proceedings, Presentations, Posters, Speeches, Lectures, etc.

Differential Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Suggest GRK5-Mediated Cardio-protection Against Mineralocorticoids, Anastasios Lymperopoulos
Faculty Proceedings, Presentations, Posters, Speeches, Lectures, etc.

Betaarrestin2 Stimulates Cardiac Function in Heart Failure Via SERCA2a Potentiation, Anastasios Lymperopoulos
Faculty Proceedings, Presentations, Posters, Speeches, Lectures, etc.

BArrestin1 and -2 in the Heart: Partners in Crime or "Good Cop, Bad Cop"?, Anastasios Lymperopoulos
Faculty Proceedings, Presentations, Posters, Speeches, Lectures, etc.

Unexpected Negative Role of the AT1R Adaptor Protein ?arrestin1 in the ERK1/2 Activation of SHR-Derived Primary Astrocytes, Shmuel Negussie, Anastasios Lymperopoulos, Michelle A. Clark
Faculty Proceedings, Presentations, Posters, Speeches, Lectures, etc.

Differential Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Suggest GRK5-Mediated Cardio-protection Against Mineralocorticoids, Anastasios Lymperopoulos, Katie Anne McCrink, Ava Brill, Jennifer Maning, Victoria Desimine, Beatrix Aukszi
Beatrix Aukszi

The Place of ARBs in Heart Failure Therapy: Is Aldosterone Suppression the Key?, Uma Markan, Samhitha Pasupuleti, Celina M. Pollard, Arianna Perez BHS Student, Beatrix Aukszi, Anastasios Lymperopoulos
Beatrix Aukszi

The Place of ARBs in Heart Failure Therapy: Is Aldosterone Suppression the Key?, Uma Markan, Samhitha Pasupuleti, Celina M. Pollard, Arianna Perez BHS Student, Beatrix Aukszi, Anastasios Lymperopoulos
Chemistry and Physics Faculty Articles

Role of βarrestin1 in AT1 R-mediated Mitogen-activated Protein Kinase Activation in Wistar and SHR Brainstem Astrocytes, Shmuel Negussie, Anastasios Lymperopoulos, Michelle A Clark
Faculty Articles

Ang II-Mediated Regulation of AGT Protein Synthesis in Rat Brainstem Astrocytes is βarrestin1 Dependent, Shmuel Negussie, Anastasios Lymperopoulos, Michelle A. Clark
Faculty Articles

GRK5 Protects the Heart against Excessive Aldosterone by Phosphorylating and Inhibiting the Cardiac Mineralocorticoid Receptor, Anastasios Lymperopoulos, Yanelys Duarte, Victoria L. Desimine, Uma Markan, Samhitha Pasupuleti, Shelby L. Wertz, Katie Anne McCrink, Jennifer Maning
Health Professions Division REACH Day

β-Arrestin2 Improves Post-Myocardial Infarction Heart Failure via Sarco(endo)plasmic Reticulum Ca2+-ATPase-Dependent Positive Inotropy in Cardiomyocytes, Katie A McCrink, Jennifer Maning, Angela Vu, Malika Jafferjee, Christine Marrero, Ava Brill, Ashley Bathgate-Siryk, Samalia Dabul, Walter J Koch, Anastasios Lymperopoulos
Faculty Articles

Biased Agonism/Antagonism at the AngII-AT1 Receptor: Implications for Adrenal Aldosterone Production and Cardiovascular Therapy, Jennifer Maning, Shmuel Negussie, Michelle A. Clark, Anastasios Lymperopoulos
Faculty Articles

Differential βarrestin1-Mediated Signaling in Spontaneously Hypertensive versus Normotensive Rat-Derived Astrocytes, Shmuel Negussie, Anastasios Lymperopoulos, Michelle A. Clark
Faculty Articles

GRK2 Regulates beta2-Adrenergic Receptor-Dependent Catecholamine Release in Human Adrenal Chromaffin Cells., Alessandro Cannavo, Daniela Liccardo, Anastasios Lymperopoulos, Michele Santangelo, Grazia D Femminella, Dario Leosco, Antonio Cittadini, Nicola Ferrara, Nazareno Paolocci, Walter J Koch, Giuseppe Rengo
Faculty Articles

Angiotensin receptor blocker drugs and inhibition of adrenal beta-arrestin-1-dependent aldosterone production: Implications for heart failure therapy., Anastasios Lymperopoulos, Beatrix Aukszi
Faculty Articles

Assays of Adrenal GPCR Signaling and Regulation: Measuring Adrenal Beta-arrestin Activity in vivo through Plasma Membrane Recruitment, Reema Mody, Yelaisy Hernandez, Anastasios Lymperopoulos
Faculty Books and Book Chapters

Hypothesis: Paroxetine, a G Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor Reduces Morbidity and Mortality in Patients With Heart Failure., Jonathan M Powell, Emanuel Ebin, Steven Borzak, Anastasios Lymperopoulos, Charles H Hennekens
Faculty Articles

Assays of adrenal GPCR signaling and regulation: Measuring adrenal β-arrestin activity in vivo through plasma membrane recruitment, Reema Mody, Yelaisy Hernandez, Anastasios Lymperopoulos
Faculty Articles

β1-adrenoceptor Arg389Gly polymorphism confers differential β-arrestin-binding tropism in cardiac myocytes, Katie A McCrink, Ava Brill, Malika Jafferjee, Thairy Reyes Valero, Christine Marrero, Martha M Rodriguez, Genevieve M. Hale, Anastasios Lymperopoulos
Faculty Articles

Autonomic Dysfunction in Critical Illness: ObNOX(2)ious (Baro)reflex Upregulation of G Protein-Coupled Receptor Kinase-2 Lets the Heart Down., Anastasios Lymperopoulos
Faculty Articles

GPCRs of adrenal chromaffin cells & catecholamines: The plot thickens., Anastasios Lymperopoulos, Ava Brill, Katie A McCrink
Faculty Articles

Structure-activity relationship study of angiotensin II analogs in terms of β-arrestin-dependent signaling to aldosterone production., Thairy Reyes Valero, Emmanuel Sturchler, Malika Jafferjee, Giuseppe Rengo, Vassiliki Magafa, Paul Cordopatis, Patricia McDonald, Walter J Koch, Anastasios Lymperopoulos
Faculty Articles

GRK2 Up-Regulation Creates a Positive Feedback Loop for Catecholamine Production in Chromaffin Cells., Malika Jafferjee, Thairy Reyes Valero, Christine Marrero, Katie A McCrink, Ava Brill, Anastasios Lymperopoulos
Faculty Articles

β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia., Alessandro Cannavo, Daniela Liccardo, Anastasios Lymperopoulos, Giuseppina Gambino, Maria Loreta D'Amico, Franco Rengo, Walter J Koch, Dario Leosco, Nicola Ferrara, Giuseppe Rengo
Faculty Articles

Angii-mediated Regulation of Beta-Arrestins Expression in Spontaneously hypertensive Rat (SHR) and Wistar Rat Astrocytes, Shmuel Negussie, Anastasios Lymperopoulos, Michelle A. Clark
Health Professions Division REACH Day

ARB DRUGS AND ALDOSTERONE IN HEART FAILURE: THE ADRENALBETA-ARRESTIN1 CONNECTION, Anastasios Lymperopoulos, Malika Jefferjee, Thairy Reyes Valero, Christine Marrero
Health Professions Division REACH Day

Neuronal Hormones and the Sympathetic/Parasympathetic Regulation of the Heart, A. Ranek, A. Vu, M. S. Willis, Anastasios Lymperopoulos
Faculty Books and Book Chapters

GPCR signaling and cardiac function, Leany A Capote, Roberto Mendez Perez, Anastasios Lymperopoulos
Faculty Articles

Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure, Katie A McCrink, Ava Brill, Anastasios Lymperopoulos
Faculty Articles

Pathophysiology of sepsis-related cardiac dysfunction: driven by inflammation, energy mismanagement, or both?, Konstantinos Drosatos, Anastasios Lymperopoulos, Peter Johannes Kennel, Nina Pollak, P Christian Schulze, Ira J Goldberg
Faculty Articles

Regulation of Catecholamine Production from the Adrenal Medulla, Anastasios Lymperopoulos, Smit Chowdhary, Kamarena Sankar, Isis Simon
Faculty Books and Book Chapters

Pathophysiology of Heart Failure, Leany Capote, Ruth Nyakundi, Brandon Martinez, Anastasios Lymperopoulos
Faculty Books and Book Chapters

The Cardiovascular Adrenergic System, Anastasios Lymperopoulos
Faculty Books and Book Chapters

Impact of CYP2D6 Genetic Variation on the Response of the Cardiovascular Patient to Carvedilol and Metoprolol., Anastasios Lymperopoulos, Katie A McCrink, Ava Brill
Faculty Articles

β1-adrenoceptor Arg389Gly polymorphism and heart disease: marching toward clinical practice integration, Katie A McCrink, Anastasios Lymperopoulos
Faculty Articles

Introduction/General Considerations, Anastasios Lymperopoulos
Faculty Books and Book Chapters

Suppression Of Adrenal βarrestin1-Dependent Aldosterone Production By ARBs: Head-To-Head Comparison., Samalia Dabul, Ashley Bathgate-Siryk, Thairy Reyes Valero, Malika Jafferjee, Emmanuel Sturchler, Patricia McDonald, Walter J Koch, Anastasios Lymperopoulos
Faculty Articles

NEGATIVE IMPACT OF BETA-ARRESTIN1 ON HEART FAILUREVIA CARDIAC AND ADRENAL DEPENDENT MECHANISMS, Anastasios Lymperopoulos, Ashley Siryk, Samalia Dabul
Health Professions Division REACH Day

Inhibition of GRK2 Augments Cardiac Beta2-Adrenergic Receptor-Dependent Contractility andSurvival, Ximena Vallejos, Khyati Desai, Anastasios Lymperopoulos
Health Professions Division REACH Day