Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2, Skye R. Doering, Katie T. Freeman, Sathya M. Schnell, Erica M. Haslach, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc A. Giulianotti, Clemencia Pinilla, Jon R. Appel, Robert Charles Speth, Richard A. Houghten, Carrie Haskell-Luevano
Robert Speth

Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist, Mark D. Ericson, Skye R. Doering, Courtney M. Larson, Katie T. Freeman, Travis M. LaVoi, Haley M. Donow, Radleigh G. Santos, Rachel H. Cho, Zoe M. Koerperich, Marc A. Giulianotti, Clemencia Pinilla, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Articles

Discovery of Selective Nanomolar Potent Melanocortin-3 Receptor Ligands, Skye R. Doering, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten, Carrie Haskell-Luevano
Radleigh Santos

Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist Versus a μM MC4R Partial Agonist, Katlyn A. Fleming, Katie T. Freeman, Mike D. Powers, Radleigh Santos, Ginamarie Debevac, Marc Giulianotti, Richard A. Houghten, Skye R. Doering, Clemencia Pinilla, Carrie Haskell-Luevano
Radleigh Santos

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens, Renee Fleeman, Ginamarie Debevec, Kirsten Antonen, Jessie L. Adams, Radleigh Santos, Greg Welmaker, Richard A. Houghten, Marc Giulianotti, Lindsey N. Shaw
Radleigh Santos

Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency, Hassan Al-Ali, Ginamarie Debevec, Radleigh Santos, Richard A. Houghten, Jennifer C. Davis, Adel Nefzi, Vance P. Lemmon, John L. Bixby, Marc A. Giulianotti
Radleigh Santos

Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist Versus a μM MC4R Partial Agonist, Katlyn A. Fleming, Katie T. Freeman, Mike D. Powers, Radleigh Santos, Ginamarie Debevac, Marc Giulianotti, Richard A. Houghten, Skye R. Doering, Clemencia Pinilla, Carrie Haskell-Luevano
Mathematics Faculty Articles

Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency, Hassan Al-Ali, Ginamarie Debevec, Radleigh Santos, Richard A. Houghten, Jennifer C. Davis, Adel Nefzi, Vance P. Lemmon, John L. Bixby, Marc A. Giulianotti
Mathematics Faculty Articles

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens, Renee Fleeman, Ginamarie Debevec, Kirsten Antonen, Jessie L. Adams, Radleigh Santos, Greg Welmaker, Richard A. Houghten, Marc Giulianotti, Lindsey N. Shaw
Mathematics Faculty Articles

Discovery of Selective Nanomolar Potent Melanocortin-3 Receptor Ligands, Skye R. Doering, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Biscyclic guanidine compound compositions, methods of use and treatment thereof, Lindsey Shaw, Renee Fleeman, Richard A. Houghten, Marc Giulianotti, Radleigh Santos, Adel Nefzi
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Melanocortin Ligands and Methods of Use Thereof, Carrie Haskell-Luevano, Skye R. Doering, Jon R. Appel, Marc Giulianotti, Richard A. Houghten, Clemencia Pinilla, Radleigh Santos
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

BIS-cyclic guanidine compound compositions, methods of use and treatment thereof, Lindsey Neil Shaw, Renee Fleeman, Richard A. Houghten, Marc Giulianotti, Radleigh Santos, Adel Nefzi
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2, Skye R. Doering, Katie T. Freeman, Sathya M. Schnell, Erica M. Haslach, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc A. Giulianotti, Clemencia Pinilla, Jon R. Appel, Robert Charles Speth, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Articles

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines, Richard A. Houghten, Michelle L. Ganno, Jay P. McLaughlin, Colette T. Dooley, Shainnel O. Eans Torrey Pines Institute for Molecular Studies, Radleigh Santos, Travis LaVoi, Adel Nefzi, Greg Welmaker, Marc A. Giulianotti, Lawrence Toll
Mathematics Faculty Articles

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities, Miao Hu, Marc Giulianotti, Jay P. McLaughlin, Jiaan Shao, Ginamarie Debevec, Laura E. Maida, Phaedra Geer, Margaret Cazares, Jaime Misler, Ling Li, Colette T. Dooley, Michelle L. Ganno, Shainnel O. Eans Torrey Pines Institute for Molecular Studies, Elisa Mizrachi, Radleigh Santos, Austin B. Yongye, Richard A. Houghten, Yongping Yu
Mathematics Faculty Articles

Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens, Renee Fleeman, Travis LaVoi, Radleigh Santos, Angela Morales, Adel Nefzi, Greg Welmaker, Jose L. Medina-Franco, Marc Giulianotti, Richard A. Houghten, Lindsey N. Shaw
Mathematics Faculty Articles

Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs), Erica M. Haslach, Huisuo Huang, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Skye R. Doering, Michael A. Walters, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Articles

Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies, Jinhua Wu, Yaohong Zhang, Laura E. Maida, Radleigh Santos, Greg Welmaker, Travis LaVoi, Adel Nefzi, Yongping Yu, Richard A. Houghten, Lawrence Toll, Marc Giulianotti
Mathematics Faculty Articles

Selective Agonists and Antagonists of Formylpeptide Receptors: Duplex Flow Cytometry and Mixture-based Positional Scanning Libraries, Clemencia Pinilla, Bruce S. Edwards, Jon R. Appel, Tina Yates-Gibbins, Marc Giulianotti, Jose L. Medina-Franco, Susan M. Young, Radleigh Santos, Larry A. Sklar, Richard A. Houghten
Mathematics Faculty Articles

Conditional Probabilistic Analysis for Prediction of the Activity Landscape and Relative Compound Activities, Radleigh Santos, Marc Giulianotti, Richard A. Houghten, Jose L. Medina-Franco
Mathematics Faculty Articles

Rapid Scanning Structure–Activity Relationships in Combinatorial Data Sets: Identification of Activity Switches, Jose L. Medina-Franco, Bruce S. Edwards, Clemencia Pinilla, Jon R. Appel, Marc Giulianotti, Radleigh Santos, Austin B. Yongye, Larry A. Sklar, Richard A. Houghten
Mathematics Faculty Articles

The Mathematics of a Successful Deconvolution: A Quantitative Assessment of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors, Radleigh Santos, Jon R. Appel, Marc Giulianotti, Bruce S. Edwards, Larry A. Sklar, Richard A. Houghten, Clemencia Pinilla
Mathematics Faculty Articles

A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries, Marc Giulianotti, Ginamarie Debevac, Radleigh Santos, Laura E. Maida, Wenteng Chen, Lili Ou, Yongping Yu, Colette T. Dooley, Richard A. Houghten
Mathematics Faculty Articles

Use and implications of the harmonic mean model on mixtures for basic research and drug discovery, Radleigh Santos, Marc Giulianotti, Colette T. Dooley, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery, Radleigh Santos, Marc Giulianotti, Colette T. Dooley, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten
Mathematics Faculty Articles