Restoring Susceptibility to Aminoglycosides: Identifying Small Molecule Inhibitors of Enzymatic Inactivation, Angel J. Magaña, Jan Sklenicka, Clemencia Pinilla, Marc Giulianotti, Prem Chapagain, Radleigh Santos, Maria Soledad Ramirez, Marcelo E. Tolmasky
Mathematics Faculty Articles

Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency, Xiaojuan Zhang, Radleigh Santos, Ginamarie Debevec, Danmeng Li, Ryan Schutte, Kien Pham, Chen Liu, David A. Ostrov, Marc Giulianotti
Radleigh Santos

Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency, Xiaojuan Zhang, Radleigh Santos, Ginamarie Debevec, Danmeng Li, Ryan Schutte, Kien Pham, Chen Liu, David A. Ostrov, Marc Giulianotti
Mathematics Faculty Articles

Identification of Peptides Combination That Successfully Block Canditatus Liberibacter asiaticus Transfer from Asian Citrus Psyllid Nymphs to Adults, Dov Borovsky, Eldesouky Ammar, Kasie Sturgeon, Erica Rose Warwick, Marc Giulianotti, Radleigh Santos, Clemencia Pinilla, Robert G. Shatters
Radleigh Santos

Discovery of Selective Nanomolar Potent Melanocortin-3 Receptor Ligands, Skye R. Doering, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten, Carrie Haskell-Luevano
Radleigh Santos

Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist Versus a μM MC4R Partial Agonist, Katlyn A. Fleming, Katie T. Freeman, Mike D. Powers, Radleigh Santos, Ginamarie Debevac, Marc Giulianotti, Richard A. Houghten, Skye R. Doering, Clemencia Pinilla, Carrie Haskell-Luevano
Radleigh Santos

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens, Renee Fleeman, Ginamarie Debevec, Kirsten Antonen, Jessie L. Adams, Radleigh Santos, Greg Welmaker, Richard A. Houghten, Marc Giulianotti, Lindsey N. Shaw
Radleigh Santos

Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist Versus a μM MC4R Partial Agonist, Katlyn A. Fleming, Katie T. Freeman, Mike D. Powers, Radleigh Santos, Ginamarie Debevac, Marc Giulianotti, Richard A. Houghten, Skye R. Doering, Clemencia Pinilla, Carrie Haskell-Luevano
Mathematics Faculty Articles

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens, Renee Fleeman, Ginamarie Debevec, Kirsten Antonen, Jessie L. Adams, Radleigh Santos, Greg Welmaker, Richard A. Houghten, Marc Giulianotti, Lindsey N. Shaw
Mathematics Faculty Articles

Identification of a Small Molecule Inhibitor of the Aminoglycoside 6'- N -acetyltransferase Type Ib [AAC(6')-Ib] Using Mixture-Based Combinatorial Libraries, Tung Tran, Kevin Chiem, Saumya Jani, Brock A. Arivett, David L. Lin, Rupali Lad, Veronica Jimenez, Mary B. Farone, Ginamarie Debevac, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Marcelo E. Tolmasky
Mathematics Faculty Articles

Discovery of Selective Nanomolar Potent Melanocortin-3 Receptor Ligands, Skye R. Doering, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Biscyclic guanidine compound compositions, methods of use and treatment thereof, Lindsey Shaw, Renee Fleeman, Richard A. Houghten, Marc Giulianotti, Radleigh Santos, Adel Nefzi
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Identification of Peptides Combination That Successfully Block Canditatus Liberibacter asiaticus Transfer from Asian Citrus Psyllid Nymphs to Adults, Dov Borovsky, Eldesouky Ammar, Kasie Sturgeon, Erica Rose Warwick, Marc Giulianotti, Radleigh Santos, Clemencia Pinilla, Robert G. Shatters
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Melanocortin Ligands and Methods of Use Thereof, Carrie Haskell-Luevano, Skye R. Doering, Jon R. Appel, Marc Giulianotti, Richard A. Houghten, Clemencia Pinilla, Radleigh Santos
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

BIS-cyclic guanidine compound compositions, methods of use and treatment thereof, Lindsey Neil Shaw, Renee Fleeman, Richard A. Houghten, Marc Giulianotti, Radleigh Santos, Adel Nefzi
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Antigen Discovery for the Identification of Vaccine Candidates and Biomarkers Using a T Cell Driven Approach in Combination with Positional Scanning Peptide Libraries, Valeria A. Judkowski, Radleigh Santos, Gonzalo R. Acevedo, Marc Giulianotti, Jon R. Appel, Silvia A. Longhi, Karina A. Gomez, Clemencia Pinilla
Mathematics Faculty Articles

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities, Miao Hu, Marc Giulianotti, Jay P. McLaughlin, Jiaan Shao, Ginamarie Debevec, Laura E. Maida, Phaedra Geer, Margaret Cazares, Jaime Misler, Ling Li, Colette T. Dooley, Michelle L. Ganno, Shainnel O. Eans Torrey Pines Institute for Molecular Studies, Elisa Mizrachi, Radleigh Santos, Austin B. Yongye, Richard A. Houghten, Yongping Yu
Mathematics Faculty Articles

Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens, Renee Fleeman, Travis LaVoi, Radleigh Santos, Angela Morales, Adel Nefzi, Greg Welmaker, Jose L. Medina-Franco, Marc Giulianotti, Richard A. Houghten, Lindsey N. Shaw
Mathematics Faculty Articles

Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs), Erica M. Haslach, Huisuo Huang, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Skye R. Doering, Michael A. Walters, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Articles

Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies, Jinhua Wu, Yaohong Zhang, Laura E. Maida, Radleigh Santos, Greg Welmaker, Travis LaVoi, Adel Nefzi, Yongping Yu, Richard A. Houghten, Lawrence Toll, Marc Giulianotti
Mathematics Faculty Articles

Selective Agonists and Antagonists of Formylpeptide Receptors: Duplex Flow Cytometry and Mixture-based Positional Scanning Libraries, Clemencia Pinilla, Bruce S. Edwards, Jon R. Appel, Tina Yates-Gibbins, Marc Giulianotti, Jose L. Medina-Franco, Susan M. Young, Radleigh Santos, Larry A. Sklar, Richard A. Houghten
Mathematics Faculty Articles

Conditional Probabilistic Analysis for Prediction of the Activity Landscape and Relative Compound Activities, Radleigh Santos, Marc Giulianotti, Richard A. Houghten, Jose L. Medina-Franco
Mathematics Faculty Articles

Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease, Michael T. Falta, Clemencia Pinilla, Douglas G. Mack, Alex N. Tinega, Francis Crawford, Marc Giulianotti, Radleigh Santos, Gina M. Clayton, Yuxiao Wang, Xuewu Zhang, Lisa A. Maier, Philippa Marrack, John W. Kappler, Andrew P. Fontenot
Mathematics Faculty Articles

Rapid Scanning Structure–Activity Relationships in Combinatorial Data Sets: Identification of Activity Switches, Jose L. Medina-Franco, Bruce S. Edwards, Clemencia Pinilla, Jon R. Appel, Marc Giulianotti, Radleigh Santos, Austin B. Yongye, Larry A. Sklar, Richard A. Houghten
Mathematics Faculty Articles

The Mathematics of a Successful Deconvolution: A Quantitative Assessment of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors, Radleigh Santos, Jon R. Appel, Marc Giulianotti, Bruce S. Edwards, Larry A. Sklar, Richard A. Houghten, Clemencia Pinilla
Mathematics Faculty Articles

A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries, Marc Giulianotti, Ginamarie Debevac, Radleigh Santos, Laura E. Maida, Wenteng Chen, Lili Ou, Yongping Yu, Colette T. Dooley, Richard A. Houghten
Mathematics Faculty Articles

Use and implications of the harmonic mean model on mixtures for basic research and drug discovery, Radleigh Santos, Marc Giulianotti, Colette T. Dooley, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

GM-CSF Production Allows the Identification of Immunoprevalent Antigens Recognized by Human CD4+ T Cells Following Smallpox Vaccination, Valeria A. Judkowski, Alcinette Bunying, Feng Ge, Jon R. Appel, Kingyee Law, Atima Sharma, Claudia Raja-Gabaglia, Patricia Norori, Radleigh Santos, Marc Giulianotti, Mark K. Slifka, Daniel C. Douek, Barney S. Graham, Clemencia Pinilla
Mathematics Faculty Articles

Characterization of a comprehensive flavor database, Karina Martinez-Mayorga, Terry L. Peppard, Austin B. Yongye, Radleigh Santos, Marc Giulianotti, Jose L. Medina-Franco
Mathematics Faculty Articles

Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery, Radleigh Santos, Marc Giulianotti, Colette T. Dooley, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten
Mathematics Faculty Articles

Towards a systematic characterization of the antiprotozoal activity landscape of benzimidazole derivatives, Jaime Perez-Villanueva, Radleigh Santos, Alicia Hernandez-Campos, Marc Giulianotti, Rafael Castillo, Jose L. Medina-Franco
Mathematics Faculty Articles

Structure–activity relationships of benzimidazole derivatives as antiparasitic agents: Dual activity-difference (DAD) maps, Jaime Perez-Villanueva, Radleigh Santos, Alicia Hernandez-Campos, Marc Giulianotti, Rafael Castillo, Jose L. Medina-Franco
Mathematics Faculty Articles