Outcomes of Transfusion With Whole Blood, Component Therapy, or Both in Adult Civilian Trauma Patients: A Systematic Review and Meta-Analysis, Micah Ngatuvai, Israel Zagales, Matthew Sauder, Ryan Andrade, Radleigh Santos, Tracy Bilski, Lucy Kornblith, Adel Elkbuli
Mathematics Faculty Articles

Restoring Susceptibility to Aminoglycosides: Identifying Small Molecule Inhibitors of Enzymatic Inactivation, Angel J. Magaña, Jan Sklenicka, Clemencia Pinilla, Marc Giulianotti, Prem Chapagain, Radleigh Santos, Maria Soledad Ramirez, Marcelo E. Tolmasky
Mathematics Faculty Articles

Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2, Skye R. Doering, Katie T. Freeman, Sathya M. Schnell, Erica M. Haslach, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc A. Giulianotti, Clemencia Pinilla, Jon R. Appel, Robert Charles Speth, Richard A. Houghten, Carrie Haskell-Luevano
Robert Speth

Outcomes of Pigtail Catheter Placement versus Chest Tube Placement in Adult Thoracic Trauma Patients: A Systematic Review and Meta-Analysis, George Beeton, Micah Ngatuvai, Tessa Breeding, Ryan Andrade, Ruth Zagales, Areeba Khan, Radleigh Santos, Adel Elkbuli
Mathematics Faculty Articles

Gender Distribution & Rank of Authorship in Surgical Literature, Sruthi Selvakumar, Israel Zagales, Kevin Newsome, Jeffrey Spardy, Radleigh Santos, Dessy Boneva, Deborah M. Stein, Lucy Kornblith, Tracy Bilski, Adel Elkbuli
Mathematics Faculty Articles

Comparing Outcomes of Appendectomy Versus Non-operative Antibiotic Therapy for Acute Appendicitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Israel Zagales, Matthew Sauder, Sruthi Selvakumar, Jeffrey Spardy, Radleigh Santos, Jozef Cruz, Tracy Bilski, Adel Elkbuli
Mathematics Faculty Articles

Beta-Blocker Therapy in Patients With Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis, Israel Zagales, Sruthi Selvakumar, Micah Ngatuvai, Dino Fanfan, Lucy Kornblith, Radleigh Santos, Joseph Ibrahim, Adel Elkbuli
Mathematics Faculty Articles

Emergency Resuscitative Thoracotomy for Civilian Thoracic Trauma in the Field and Emergency Department Settings: A Systematic Review and Meta-Analysis, Amy Liu, Jackie Nguyen, Haley Ehrlich, Charles Bisbee, Luis Santiesteban, Radleigh Santos, Mark McKenney, Adel Elkbuli
Mathematics Faculty Articles

Effectiveness and Safety of Tranexamic Acid Use in Acute Traumatic Injury in the Prehospital and In-hospital Settings: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Scott Rowe, Amy Liu, Israel Zagales, Muhammad Awan, Radleigh Santos, Mark McKenney, Adel Elkbuli
Mathematics Faculty Articles

Inhibition of Aminoglycoside 6’-N-Acetyltransferase Type Ib [Aac(6′)-Ib]: Structure-Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors, Kenneth Rocha, Jesus Magallon, Craig Reeves, Kimberly Phan, Peter Vu, Crista L. Oakley-Havens, Stella Kwan, Maria S. Ramirez, Travis LaVoi, Haley Donow, Prem Chapagain, Radleigh Santos, Clemencia Pinilla, Marc A. Giulianotti, Marcelo E. Tolmasky
Mathematics Faculty Articles

CD4+ T Cells in the Lungs of Acute Sarcoidosis Patients Recognize an Aspergillus Nidulans Epitope, Sarah A. Greaves, Avinash Ravindran, Radleigh Santos, Lan Chen, Michael T. Falta, Yang Wang, Angela M. Mitchell, Shaikh M. Atif, Douglas G. Mack, Alex N. Tinega, Lisa A. Maier, Shaodong Dai, Clemencia Pinilla, Johan Grunewald, Andrew P. Fontenot
Mathematics Faculty Articles

The Relationship Between COVID-19 Infection Rates and Social Determinants of Health in Broward and Miami-Dade Counties, Florida, Lindsey A. Taylor, Jarrod Sheehan, Ariel T. Paz, Monica Tromer, Erica Pieper, Iman Squires, Aysha Nuhuman, Radleigh Santos, Robin Jacobs
Mathematics Faculty Articles

Disparities in Adult and Pediatric Trauma Outcomes: a Systematic Review and Meta-Analysis, Carol Sanchez, Saamia Shaikh, Brianna Dowd, Radleigh Santos, Mark McKenney, Adel Elkbuli
Radleigh Santos

Beryllium-specific CD4+ T cells induced by chemokine neoantigens perpetuate inflammation, Michael T. Falta, Jeremy C. Crawford, Alex N. Tinega, Laurie G. Landry, Frances Crawford, Douglas G. Mack, Allison K. Martin, Shaikh M. Atif, Li Li, Radleigh Santos, Maki Nakayama, John W. Kappler, Lisa A. Maier, Paul G. Thomas, Clemencia Pinilla, Andrew Fontenot
Radleigh Santos

Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency, Xiaojuan Zhang, Radleigh Santos, Ginamarie Debevec, Danmeng Li, Ryan Schutte, Kien Pham, Chen Liu, David A. Ostrov, Marc Giulianotti
Radleigh Santos

Association of Hypothermia with Increased Mortality Rate in SARS-CoV-2 Infection, Naaz Fatteh, Glen E. Sutherland, Radleigh Santos, Rita Zeidan, Alexandra P. Gastesi, Christopher D. Naranjo
Mathematics Faculty Articles

Beryllium-specific CD4+ T cells induced by chemokine neoantigens perpetuate inflammation, Michael T. Falta, Jeremy C. Crawford, Alex N. Tinega, Laurie G. Landry, Frances Crawford, Douglas G. Mack, Allison K. Martin, Shaikh M. Atif, Li Li, Radleigh Santos, Maki Nakayama, John W. Kappler, Lisa A. Maier, Paul G. Thomas, Clemencia Pinilla, Andrew Fontenot
Mathematics Faculty Articles

Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency, Xiaojuan Zhang, Radleigh Santos, Ginamarie Debevec, Danmeng Li, Ryan Schutte, Kien Pham, Chen Liu, David A. Ostrov, Marc Giulianotti
Mathematics Faculty Articles

Identification of Peptides Combination That Successfully Block Canditatus Liberibacter asiaticus Transfer from Asian Citrus Psyllid Nymphs to Adults, Dov Borovsky, Eldesouky Ammar, Kasie Sturgeon, Erica Rose Warwick, Marc Giulianotti, Radleigh Santos, Clemencia Pinilla, Robert G. Shatters
Radleigh Santos

High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems, Mark Haynes, Matthew Garcia, Ryan Peters, Anna Waller, Pietro Tedesco, Oleg Ursu, Cristian G. Bologa, Radleigh Santos, Clemencia Pinilla, Terry H. Wu, Julie A. Lovchik, Tudor I. Oprea, Larry A. Sklar, George P. Tegos
Radleigh Santos

CD4+ T Cell Antigen Discovery in Sarcoidosis, Sarah A. Greaves, Angela Mitchell, Michael Falta, Radleigh Santos, Clemencia Pinilla, Andrew P. Fontenot
Radleigh Santos

Discovery of Selective Nanomolar Potent Melanocortin-3 Receptor Ligands, Skye R. Doering, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten, Carrie Haskell-Luevano
Radleigh Santos

A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma, Patrick Y. Wen, David A. Reardon, Terri S. Armstrong, Surasak Phupanich, Robert D. Aiken, Joseph C. Landolfi, William T. Curry, Jay-Jiguang Zhu, Michael Glantz, David M. Peereboom, James M. Markert, Renato LaRocca, Donald M. O'Rourke, Karen Fink, Lyndon Kim, Michael Gruber, Glenn J. Lesser, Edward Pan, Santosh Kesari, Alona Muzikansky, Clemencia Pinilla, Radleigh Santos, John S. Yu
Radleigh Santos

GDP-L-Fucose Synthase is a CD4+ T Cell–Specific Autoantigen in DRB3*02:02 Patients with Multiple Sclerosis, Raquel Planas, Radleigh Santos, Paula Tomas-Ojer, Carolina Cruciani, Andreas Lutterotti, Wolfgang Faigle, Nicole Schaeren-Wiemers, Carmen Espejo, Herena Eixarch, Clemencia Pinilla, Roland Martin, Mireia Sospedra
Radleigh Santos

Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist Versus a μM MC4R Partial Agonist, Katlyn A. Fleming, Katie T. Freeman, Mike D. Powers, Radleigh Santos, Ginamarie Debevac, Marc Giulianotti, Richard A. Houghten, Skye R. Doering, Clemencia Pinilla, Carrie Haskell-Luevano
Radleigh Santos

B - T Cell Interactions Activate and Maintain Brain-Homing T Cells in Multiple Sclerosis, I. Jelcic, F. Al Nimer, J. Wang, V. Lentsch, R. Planas, A. Madjovski, W. Faigle, Clemencia Pinilla, Radleigh Santos, C. Hammer, Y. Ortiz, L. Opitz, M. Khademi, A. Lutterotti, T. Olsson, F. Piehl, M. Sospedra, R. Martin
Radleigh Santos

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens, Renee Fleeman, Ginamarie Debevec, Kirsten Antonen, Jessie L. Adams, Radleigh Santos, Greg Welmaker, Richard A. Houghten, Marc Giulianotti, Lindsey N. Shaw
Radleigh Santos

Polyamine Compounds Targeting the Efflux Pumps of Multi-Drug Resistant Bacterial Pathogens and Methods of Using the Same, Renee Fleeman, Radleigh Santos, Marcello Angelo Giulianotti, Lindsey Shaw
Radleigh Santos

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis, Ivan Jelcic, Faiez Al Nimer, Jian Wang, Verena Lentsch, Raquel Planas, Ilijas Jelcic, Aleksandar Madjovski, Sabrina Ruhrmann, Wolfgang Faigle, Katrin Frauenknecht, Clemencia Pinilla, Radleigh Santos, Christian Hammer, Yanneth Ortiz, Lennart Opitz, Hans Gronlund, Gerhard Rogler, Onur Boyman, Richard Reynolds, Andreas Lutterotti, Mohsen Khademi, Tomas Olsson, Frederik Piehl, Mireia Sospedra, Roland Martin
Radleigh Santos

Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency, Hassan Al-Ali, Ginamarie Debevec, Radleigh Santos, Richard A. Houghten, Jennifer C. Davis, Adel Nefzi, Vance P. Lemmon, John L. Bixby, Marc A. Giulianotti
Radleigh Santos

Disparities in Adult and Pediatric Trauma Outcomes: a Systematic Review and Meta-Analysis, Carol Sanchez, Saamia Shaikh, Brianna Dowd, Radleigh Santos, Mark McKenney, Adel Elkbuli
Mathematics Faculty Articles

A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma, Patrick Y. Wen, David A. Reardon, Terri S. Armstrong, Surasak Phupanich, Robert D. Aiken, Joseph C. Landolfi, William T. Curry, Jay-Jiguang Zhu, Michael Glantz, David M. Peereboom, James M. Markert, Renato LaRocca, Donald M. O'Rourke, Karen Fink, Lyndon Kim, Michael Gruber, Glenn J. Lesser, Edward Pan, Santosh Kesari, Alona Muzikansky, Clemencia Pinilla, Radleigh Santos, John S. Yu
Mathematics Faculty Articles

Polyamine Compounds Targeting the Efflux Pumps of Multi-Drug Resistant Bacterial Pathogens and Methods of Using the Same, Renee Fleeman, Radleigh Santos, Marcello Angelo Giulianotti, Lindsey Shaw
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

CD4+ T Cell Antigen Discovery in Sarcoidosis, Sarah A. Greaves, Angela Mitchell, Michael Falta, Radleigh Santos, Clemencia Pinilla, Andrew P. Fontenot
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist Versus a μM MC4R Partial Agonist, Katlyn A. Fleming, Katie T. Freeman, Mike D. Powers, Radleigh Santos, Ginamarie Debevac, Marc Giulianotti, Richard A. Houghten, Skye R. Doering, Clemencia Pinilla, Carrie Haskell-Luevano
Mathematics Faculty Articles

B - T Cell Interactions Activate and Maintain Brain-Homing T Cells in Multiple Sclerosis, I. Jelcic, F. Al Nimer, J. Wang, V. Lentsch, R. Planas, A. Madjovski, W. Faigle, Clemencia Pinilla, Radleigh Santos, C. Hammer, Y. Ortiz, L. Opitz, M. Khademi, A. Lutterotti, T. Olsson, F. Piehl, M. Sospedra, R. Martin
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

GDP-L-Fucose Synthase is a CD4+ T Cell–Specific Autoantigen in DRB3*02:02 Patients with Multiple Sclerosis, Raquel Planas, Radleigh Santos, Paula Tomas-Ojer, Carolina Cruciani, Andreas Lutterotti, Wolfgang Faigle, Nicole Schaeren-Wiemers, Carmen Espejo, Herena Eixarch, Clemencia Pinilla, Roland Martin, Mireia Sospedra
Mathematics Faculty Articles

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis, Ivan Jelcic, Faiez Al Nimer, Jian Wang, Verena Lentsch, Raquel Planas, Ilijas Jelcic, Aleksandar Madjovski, Sabrina Ruhrmann, Wolfgang Faigle, Katrin Frauenknecht, Clemencia Pinilla, Radleigh Santos, Christian Hammer, Yanneth Ortiz, Lennart Opitz, Hans Gronlund, Gerhard Rogler, Onur Boyman, Richard Reynolds, Andreas Lutterotti, Mohsen Khademi, Tomas Olsson, Frederik Piehl, Mireia Sospedra, Roland Martin
Mathematics Faculty Articles

Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency, Hassan Al-Ali, Ginamarie Debevec, Radleigh Santos, Richard A. Houghten, Jennifer C. Davis, Adel Nefzi, Vance P. Lemmon, John L. Bixby, Marc A. Giulianotti
Mathematics Faculty Articles

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens, Renee Fleeman, Ginamarie Debevec, Kirsten Antonen, Jessie L. Adams, Radleigh Santos, Greg Welmaker, Richard A. Houghten, Marc Giulianotti, Lindsey N. Shaw
Mathematics Faculty Articles

Identification of a Small Molecule Inhibitor of the Aminoglycoside 6'- N -acetyltransferase Type Ib [AAC(6')-Ib] Using Mixture-Based Combinatorial Libraries, Tung Tran, Kevin Chiem, Saumya Jani, Brock A. Arivett, David L. Lin, Rupali Lad, Veronica Jimenez, Mary B. Farone, Ginamarie Debevac, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Marcelo E. Tolmasky
Mathematics Faculty Articles

Discovery of Selective Nanomolar Potent Melanocortin-3 Receptor Ligands, Skye R. Doering, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Biscyclic guanidine compound compositions, methods of use and treatment thereof, Lindsey Shaw, Renee Fleeman, Richard A. Houghten, Marc Giulianotti, Radleigh Santos, Adel Nefzi
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems, Mark Haynes, Matthew Garcia, Ryan Peters, Anna Waller, Pietro Tedesco, Oleg Ursu, Cristian G. Bologa, Radleigh Santos, Clemencia Pinilla, Terry H. Wu, Julie A. Lovchik, Tudor I. Oprea, Larry A. Sklar, George P. Tegos
Mathematics Faculty Books and Book Chapters

Identification of Peptides Combination That Successfully Block Canditatus Liberibacter asiaticus Transfer from Asian Citrus Psyllid Nymphs to Adults, Dov Borovsky, Eldesouky Ammar, Kasie Sturgeon, Erica Rose Warwick, Marc Giulianotti, Radleigh Santos, Clemencia Pinilla, Robert G. Shatters
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Melanocortin Ligands and Methods of Use Thereof, Carrie Haskell-Luevano, Skye R. Doering, Jon R. Appel, Marc Giulianotti, Richard A. Houghten, Clemencia Pinilla, Radleigh Santos
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

BIS-cyclic guanidine compound compositions, methods of use and treatment thereof, Lindsey Neil Shaw, Renee Fleeman, Richard A. Houghten, Marc Giulianotti, Radleigh Santos, Adel Nefzi
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Methodological approach to the ex vivo expansion and detection of T. cruzi-specific T cells from chronic Chagas disease patients, Gonzalo R. Acevedo, Silvia A. Longhi, Alcinette Bunying, Nazila Sabri, Augusto Atienza, Maria P. Zago, Radleigh Santos, Valeria A. Judkowski, Clemencia Pinilla, Karina A. Gomez
Mathematics Faculty Articles

Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2, Skye R. Doering, Katie T. Freeman, Sathya M. Schnell, Erica M. Haslach, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc A. Giulianotti, Clemencia Pinilla, Jon R. Appel, Robert Charles Speth, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Articles

Calcium Transient Assays for Compound Screening with Human iPSC-derived Cardiomyocytes: Evaluating New Tools, Neil J. Daily, Radleigh Santos, Joseph Vecchi, Pinar Kemanli, Tetsuro Wakatsuki
Mathematics Faculty Articles

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate, Franck Madoux, Daniela Dreymuller, Jean-Phillipe Pettiloud, Radleigh Santos, Christoph Becker-Pauly, Andreas Ludwig, Gregg B. Fields, Thomas Bannister, Timothy P. Spicer, Mare Cudic, Louis D. Scampavia, Dmitriy Minond
Mathematics Faculty Articles

Categorizing immune responders with fusion metrics and simulation for association to survival & progression free survival with immune response in HLA-A2+ patients with GBM from a phase 2 trial of dendritic cell (DC) immunotherapy (ICT-107)., Radleigh Santos, Clemencia Pinilla, Steve J. Swanson, Anthony Gringeri, John Yu
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Using Fusion of Response Metrics and Monte Carlo Simulation to Determine Immune Response in Cancer Immunotherapy Patients, Radleigh Santos, Alcinette Bunying, Nazila Sabri, John Yu, Steve J. Swanson, Valeria A. Judkowski, Pedro Romero, Sylvia Janetzki, Clemencia Pinilla
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library, Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh Santos, Marc A. Giulianotti, Robert J. Deschenes
Mathematics Faculty Articles

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines, Richard A. Houghten, Michelle L. Ganno, Jay P. McLaughlin, Colette T. Dooley, Shainnel O. Eans Torrey Pines Institute for Molecular Studies, Radleigh Santos, Travis LaVoi, Adel Nefzi, Greg Welmaker, Marc A. Giulianotti, Lawrence Toll
Mathematics Faculty Articles

Association of Survival and Progression-Free Survival with Immune Response in HLA-A2+ Newly- Diagnosed GBM Patients in Randomized Double-Blind Placebo-Controlled Phase 2 Trial of Dentritic Cell (DC) Immunotherapy with ICT-107, Patrick Wen, David Reardon, Surasak Phuphanich, Robert Aiken, Joseph Landolfi, William Curry, Jay-Jiguang Zhu, Michael Glantz, David Peereboom, James Markert, Renato Larocca, Donald O'Rourke, Karen Fink, Lyndon Kim, Michael Gruber, Glenn Lesser, Ed Pan, Radleigh Santos, Clemencia Pinilla, John Yu
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Statistically significant association of glioblastoma immunotherapy phase II clinical study (ICT-107) treatment and survival to immune response using a novel comprehensive ELISPOT analysis., Radleigh Santos, Anthony Gringeri, John Yu, Sylvia Janetzki, Valeria A. Judkowski, Clemencia Pinilla
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Investigating the Role of the Host Multidrug Resistance Associated Protein Transporter Family in Burkholderia cepacia Complex Pathogenicity Using a Caenorhabditis elegans Infection Model, Pietro Tedesco, Marco Visone, Ermenegilda Parrilli, Maria Luisa Tutino, Elena Perrin, Isabel Maida, Renato Fani, Francesco Ballestriero, Radleigh Santos, Clemencia Pinilla, Elia Di Schiavi, George Tegos, Donatella de Pascale
Mathematics Faculty Articles

Antigen Discovery for the Identification of Vaccine Candidates and Biomarkers Using a T Cell Driven Approach in Combination with Positional Scanning Peptide Libraries, Valeria A. Judkowski, Radleigh Santos, Gonzalo R. Acevedo, Marc Giulianotti, Jon R. Appel, Silvia A. Longhi, Karina A. Gomez, Clemencia Pinilla
Mathematics Faculty Articles

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities, Miao Hu, Marc Giulianotti, Jay P. McLaughlin, Jiaan Shao, Ginamarie Debevec, Laura E. Maida, Phaedra Geer, Margaret Cazares, Jaime Misler, Ling Li, Colette T. Dooley, Michelle L. Ganno, Shainnel O. Eans Torrey Pines Institute for Molecular Studies, Elisa Mizrachi, Radleigh Santos, Austin B. Yongye, Richard A. Houghten, Yongping Yu
Mathematics Faculty Articles

Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens, Renee Fleeman, Travis LaVoi, Radleigh Santos, Angela Morales, Adel Nefzi, Greg Welmaker, Jose L. Medina-Franco, Marc Giulianotti, Richard A. Houghten, Lindsey N. Shaw
Mathematics Faculty Articles

Improvement of IFNg ELISPOT Performance Following Overnight Resting of Frozen PBMC Samples Confirmed Through Rigorous Statistical Analysis, Radleigh Santos, Alcinette Bunying, Nazila Sabri, John Yu, Anthony Gringeri, James Bender, Sylvia Janetzki, Clemencia Pinilla, Valeria A. Judkowski
Mathematics Faculty Articles

Cytokine Production but Lack of Proliferation in Peripheral Blood Mononuclear Cells from Chronic Chagas' Disease Cardiomyopathy Patients in Response to T. cruzi Ribosomal P Proteins, Silvia A. Longhi, Augusto Atienza, Graciela Perez Prados, Alcinette Buying, Virginia Balouz, Carlos A. Buscaglia, Radleigh Santos, Laura M. Tasso, Ricardo Bonato, Pablo Chiale, Clemencia Pinilla, Valeria A. Judkowski, Karina A. Gomez
Mathematics Faculty Articles

Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs), Erica M. Haslach, Huisuo Huang, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Skye R. Doering, Michael A. Walters, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Articles

Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies, Jinhua Wu, Yaohong Zhang, Laura E. Maida, Radleigh Santos, Greg Welmaker, Travis LaVoi, Adel Nefzi, Yongping Yu, Richard A. Houghten, Lawrence Toll, Marc Giulianotti
Mathematics Faculty Articles

Selective Agonists and Antagonists of Formylpeptide Receptors: Duplex Flow Cytometry and Mixture-based Positional Scanning Libraries, Clemencia Pinilla, Bruce S. Edwards, Jon R. Appel, Tina Yates-Gibbins, Marc Giulianotti, Jose L. Medina-Franco, Susan M. Young, Radleigh Santos, Larry A. Sklar, Richard A. Houghten
Mathematics Faculty Articles

Conditional Probabilistic Analysis for Prediction of the Activity Landscape and Relative Compound Activities, Radleigh Santos, Marc Giulianotti, Richard A. Houghten, Jose L. Medina-Franco
Mathematics Faculty Articles

Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease, Michael T. Falta, Clemencia Pinilla, Douglas G. Mack, Alex N. Tinega, Francis Crawford, Marc Giulianotti, Radleigh Santos, Gina M. Clayton, Yuxiao Wang, Xuewu Zhang, Lisa A. Maier, Philippa Marrack, John W. Kappler, Andrew P. Fontenot
Mathematics Faculty Articles

Rapid Scanning Structure–Activity Relationships in Combinatorial Data Sets: Identification of Activity Switches, Jose L. Medina-Franco, Bruce S. Edwards, Clemencia Pinilla, Jon R. Appel, Marc Giulianotti, Radleigh Santos, Austin B. Yongye, Larry A. Sklar, Richard A. Houghten
Mathematics Faculty Articles

The Mathematics of a Successful Deconvolution: A Quantitative Assessment of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors, Radleigh Santos, Jon R. Appel, Marc Giulianotti, Bruce S. Edwards, Larry A. Sklar, Richard A. Houghten, Clemencia Pinilla
Mathematics Faculty Articles

A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries, Marc Giulianotti, Ginamarie Debevac, Radleigh Santos, Laura E. Maida, Wenteng Chen, Lili Ou, Yongping Yu, Colette T. Dooley, Richard A. Houghten
Mathematics Faculty Articles

Use and implications of the harmonic mean model on mixtures for basic research and drug discovery, Radleigh Santos, Marc Giulianotti, Colette T. Dooley, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

GM-CSF Production Allows the Identification of Immunoprevalent Antigens Recognized by Human CD4+ T Cells Following Smallpox Vaccination, Valeria A. Judkowski, Alcinette Bunying, Feng Ge, Jon R. Appel, Kingyee Law, Atima Sharma, Claudia Raja-Gabaglia, Patricia Norori, Radleigh Santos, Marc Giulianotti, Mark K. Slifka, Daniel C. Douek, Barney S. Graham, Clemencia Pinilla
Mathematics Faculty Articles

Characterization of a comprehensive flavor database, Karina Martinez-Mayorga, Terry L. Peppard, Austin B. Yongye, Radleigh Santos, Marc Giulianotti, Jose L. Medina-Franco
Mathematics Faculty Articles

Consensus Models of Activity Landscapes with Multiple Chemical, Conformer, and Property Representations, Austin B. Yongye, Kendall Byler, Radleigh Santos, Karina Martinez-Mayorga, Gerald M. Maggiora, Jose L. Medina-Franco
Mathematics Faculty Articles

Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery, Radleigh Santos, Marc Giulianotti, Colette T. Dooley, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten
Mathematics Faculty Articles

Towards a systematic characterization of the antiprotozoal activity landscape of benzimidazole derivatives, Jaime Perez-Villanueva, Radleigh Santos, Alicia Hernandez-Campos, Marc Giulianotti, Rafael Castillo, Jose L. Medina-Franco
Mathematics Faculty Articles

Structure–activity relationships of benzimidazole derivatives as antiparasitic agents: Dual activity-difference (DAD) maps, Jaime Perez-Villanueva, Radleigh Santos, Alicia Hernandez-Campos, Marc Giulianotti, Rafael Castillo, Jose L. Medina-Franco
Mathematics Faculty Articles