Part of the Physical Sciences and Mathematics Commons

Works by Jon R. Appel in Physical Sciences and Mathematics

2023

Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2, Skye R. Doering, Katie T. Freeman, Sathya M. Schnell, Erica M. Haslach, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc A. Giulianotti, Clemencia Pinilla, Jon R. Appel, Robert Charles Speth, Richard A. Houghten, Carrie Haskell-Luevano
Robert Speth

2020

Discovery of Selective Nanomolar Potent Melanocortin-3 Receptor Ligands, Skye R. Doering, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten, Carrie Haskell-Luevano
Radleigh Santos

2018

Discovery of Selective Nanomolar Potent Melanocortin-3 Receptor Ligands, Skye R. Doering, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

2017

Melanocortin Ligands and Methods of Use Thereof, Carrie Haskell-Luevano, Skye R. Doering, Jon R. Appel, Marc Giulianotti, Richard A. Houghten, Clemencia Pinilla, Radleigh Santos
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2, Skye R. Doering, Katie T. Freeman, Sathya M. Schnell, Erica M. Haslach, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc A. Giulianotti, Clemencia Pinilla, Jon R. Appel, Robert Charles Speth, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Articles

2015

Antigen Discovery for the Identification of Vaccine Candidates and Biomarkers Using a T Cell Driven Approach in Combination with Positional Scanning Peptide Libraries, Valeria A. Judkowski, Radleigh Santos, Gonzalo R. Acevedo, Marc Giulianotti, Jon R. Appel, Silvia A. Longhi, Karina A. Gomez, Clemencia Pinilla
Mathematics Faculty Articles

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2014

Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs), Erica M. Haslach, Huisuo Huang, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Skye R. Doering, Michael A. Walters, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Articles

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2013

Selective Agonists and Antagonists of Formylpeptide Receptors: Duplex Flow Cytometry and Mixture-based Positional Scanning Libraries, Clemencia Pinilla, Bruce S. Edwards, Jon R. Appel, Tina Yates-Gibbins, Marc Giulianotti, Jose L. Medina-Franco, Susan M. Young, Radleigh Santos, Larry A. Sklar, Richard A. Houghten
Mathematics Faculty Articles

Rapid Scanning Structure–Activity Relationships in Combinatorial Data Sets: Identification of Activity Switches, Jose L. Medina-Franco, Bruce S. Edwards, Clemencia Pinilla, Jon R. Appel, Marc Giulianotti, Radleigh Santos, Austin B. Yongye, Larry A. Sklar, Richard A. Houghten
Mathematics Faculty Articles

The Mathematics of a Successful Deconvolution: A Quantitative Assessment of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors, Radleigh Santos, Jon R. Appel, Marc Giulianotti, Bruce S. Edwards, Larry A. Sklar, Richard A. Houghten, Clemencia Pinilla
Mathematics Faculty Articles

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2012

Use and implications of the harmonic mean model on mixtures for basic research and drug discovery, Radleigh Santos, Marc Giulianotti, Colette T. Dooley, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten
Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Novel T cell driven approach leads to the identification of immunoprevalent antigens, Valeria A. Judkowski, Radleigh G. Santos, Alcinette Bunying, Marc A. Giulianotti, Jon R. Appel, Clemencia Pinilla
Mathematics Faculty Articles

2011

GM-CSF Production Allows the Identification of Immunoprevalent Antigens Recognized by Human CD4+ T Cells Following Smallpox Vaccination, Valeria A. Judkowski, Alcinette Bunying, Feng Ge, Jon R. Appel, Kingyee Law, Atima Sharma, Claudia Raja-Gabaglia, Patricia Norori, Radleigh Santos, Marc Giulianotti, Mark K. Slifka, Daniel C. Douek, Barney S. Graham, Clemencia Pinilla
Mathematics Faculty Articles

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Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery, Radleigh Santos, Marc Giulianotti, Colette T. Dooley, Clemencia Pinilla, Jon R. Appel, Richard A. Houghten
Mathematics Faculty Articles