Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2, Skye R. Doering, Katie T. Freeman, Sathya M. Schnell, Erica M. Haslach, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc A. Giulianotti, Clemencia Pinilla, Jon R. Appel, Robert Charles Speth, Richard A. Houghten, Carrie Haskell-Luevano
Robert Speth

Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency, Xiaojuan Zhang, Radleigh Santos, Ginamarie Debevec, Danmeng Li, Ryan Schutte, Kien Pham, Chen Liu, David A. Ostrov, Marc Giulianotti
Radleigh Santos

Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency, Xiaojuan Zhang, Radleigh Santos, Ginamarie Debevec, Danmeng Li, Ryan Schutte, Kien Pham, Chen Liu, David A. Ostrov, Marc Giulianotti
Mathematics Faculty Articles

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens, Renee Fleeman, Ginamarie Debevec, Kirsten Antonen, Jessie L. Adams, Radleigh Santos, Greg Welmaker, Richard A. Houghten, Marc Giulianotti, Lindsey N. Shaw
Radleigh Santos

Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency, Hassan Al-Ali, Ginamarie Debevec, Radleigh Santos, Richard A. Houghten, Jennifer C. Davis, Adel Nefzi, Vance P. Lemmon, John L. Bixby, Marc A. Giulianotti
Radleigh Santos

Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency, Hassan Al-Ali, Ginamarie Debevec, Radleigh Santos, Richard A. Houghten, Jennifer C. Davis, Adel Nefzi, Vance P. Lemmon, John L. Bixby, Marc A. Giulianotti
Mathematics Faculty Articles

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens, Renee Fleeman, Ginamarie Debevec, Kirsten Antonen, Jessie L. Adams, Radleigh Santos, Greg Welmaker, Richard A. Houghten, Marc Giulianotti, Lindsey N. Shaw
Mathematics Faculty Articles

Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2, Skye R. Doering, Katie T. Freeman, Sathya M. Schnell, Erica M. Haslach, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc A. Giulianotti, Clemencia Pinilla, Jon R. Appel, Robert Charles Speth, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Articles

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities, Miao Hu, Marc Giulianotti, Jay P. McLaughlin, Jiaan Shao, Ginamarie Debevec, Laura E. Maida, Phaedra Geer, Margaret Cazares, Jaime Misler, Ling Li, Colette T. Dooley, Michelle L. Ganno, Shainnel O. Eans Torrey Pines Institute for Molecular Studies, Elisa Mizrachi, Radleigh Santos, Austin B. Yongye, Richard A. Houghten, Yongping Yu
Mathematics Faculty Articles

Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs), Erica M. Haslach, Huisuo Huang, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Skye R. Doering, Michael A. Walters, Richard A. Houghten, Carrie Haskell-Luevano
Mathematics Faculty Articles