Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Event Name/Location

BIOMATH 2015 International Conference on Mathematical Methods and Models in Biosciences and Young Scientists School, Blagoevgrad, Bulgaria, June 14-19, 2015

Document Type

Conference Proceeding

Publication Date



Seasonal infections by Influenza A virus (IAV) causes hundreds of thousands of deaths worldwide each year, with most individuals being infected multiple times throughout their lifetimes. The relative impact of the components of the host immune system in controlling the severity and duration of repeated challenges from an IAV infection remains unclear. In particular, the differential contribution of the humoral immune response in primary and secondary challenges from IAV are relatively little explored. We develop a parsimonious mathematical model of the humoral immune response to IAV infection with biologically meaningful and identifiable parameters. We show the relative sensitivity of the viral load and antibody response to dynamics of B cell proliferation and antibody production. We relate immunoglobin class switching to a CD4+ T-cell driven process for the formation of humoral memory. Results of this study help to illuminate the relative contribution of CD4+ T-cells, B-cells, and antibody in the control of IAV infection and formation of humoral memory.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Additional Comments

NSU President's Faculty Research and Development grant #: 335321

Conference Proceeding Title

Biomath Communications v. 2 no. 1




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