Biology Faculty Proceedings, Presentations, Speeches, Lectures

Title

Linking Protein Structure and Function to Medical Applications Through 3-D Molecular Modeling

Event Name/Location

Human Anatomy and Physiology Society Southern Regional Conference, Fort Lauderdale, Florida, October 22, 2016

Document Type

Conference Proceeding

Publication Date

10-22-2016

Abstract

Through the use of protein visualization software, such as JMOL, it is possible to design and ultimately print 3-D structural protein models. Literary review and protein database files help shed light on the important structural components of proteins. As an example, the Angiotensin II, AT1 type receptor, known by its protein database file, 4ZUD, was selected to demonstrate this process. We observed its interaction with a well-known anti-hypertensive drug, Benicar™ (olmesartan), to better explain the structure and function of this drug and its receptor. 3-D molecular modeling is a valuable tool for visually understanding and identifying anatomical and physiological relationships.

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