Title

D1S80 Single-Locus Discrimination Among African Populations

Authors

Rene J. Herrera, Florida International University
Leslie R. Adrien, Florida International University
Luis M. Ruiz, Florida International University
Nahir Y. Sanabria, Florida International University
George Duncan, Broward County Sheriff's OfficeFollow

Document Type

Article

Publication Date

2-2004

Publication Title

Human Biology

Keywords

D1S80, AmpliFLPS, PCR, African populations, Benin, Cameroon, Egypt, Kenya, Rwanda, Phylogenetic analysis, Population genetics, Variable number of tandem repeats (VNTR)

ISSN

0018-7143

Volume

76

Issue/No.

1

First Page

87

Last Page

108

Abstract

The highly polymorphic D1S80 locus has no known genetic function. However, this variable number of tandem repeats (VNTR) locus has been highly valuable in forensic identification. In this study we report the allele and genotype frequencies of five African populations (Benin, Cameroon, Egypt, Kenya, and Rwanda), which can be used as databases to help characterize populations and identify individuals. The allele frequencies were used to infer genetic associations through phylogenetic, principal component, and G test statistical analyses. Compliance with Hardy-Weinberg equilibrium expectations was determined as were F_ST estimates, theta p values, and power of discrimination assessment for each population. Our analyses of 28 additional populations demonstrate that the D1S80 locus alone can be used to discriminate geographic and ethnic groups. We have generated databases useful for human identification and phylogenetic studies.

Comments

©2004 Wayne State University Press

Additional Comments

National Institutes of Health grant #s: GM 08205

NSUWorks Citation

Herrera, Rene J.; Leslie R. Adrien; Luis M. Ruiz; Nahir Y. Sanabria; and George Duncan. 2004. "D1S80 Single-Locus Discrimination Among African Populations." Human Biology 76, (1): 87-108. doi:10.1353/hub.2004.0022.

ORCID ID

0000-0002-4931-5316

DOI

10.1353/hub.2004.0022