Biology Faculty Articles
Title
Y chromosome STR allelic and haplotype diversity in a Rwanda population from East Central Africa
Document Type
Article
Publication Date
3-1-2012
Publication Title
Legal Medicine
Keywords
Y-STR, Rwanda population, African population, Y-STR haplotypes, Gene diversity, Genetic disease
ISSN
1344-6223
Volume
14
Issue/No.
2
First Page
105
Last Page
109
Abstract
We have analyzed 17 Y-chromosomal STR loci in a population sample of 69 unrelated male individuals of the Rwanda-Hutu population from East Central Africa using an AmpF l STR® Yfiler™ PCR amplification kit. A total of 62 unique haplotypes were identified among the 69 individuals studied. The haplotype diversity was found to be 0.9970 for this population. The gene diversity ranged from 0.1130 (DYS392) to 0.7722 (DYS385). Comparison of populations in this study with twenty-five other national and global populations using Principal Co-ordinate Analysis (PCA) and phylogenetic molecular analysis using a genetic distance matrix indicates a delineation of all the African populations from other unrelated populations. The results of population pair-wise Fst p values indicate statistically significant differentiation of the Rwandan population when compared with 25 other global populations including four African populations ( p = 0.0000). Analysis of Molecular Variance (AMOVA) of the Rwanda population with four other African populations indicated a 93% variance within populations and 7% variance among the five populations. A data base search of the 62 haplotypes yielded only one non-African haplotype match, suggesting these haplotypes are unique to the African continent.
NSUWorks Citation
Balamurugan, Kuppareddi and George Duncan. 2012. "Y chromosome STR allelic and haplotype diversity in a Rwanda population from East Central Africa." Legal Medicine 14, (2): 105-109. doi:10.1016/j.legalmed.2011.12.002.
DOI
10.1016/j.legalmed.2011.12.002
Comments
Copyright © 2011 Elsevier Ireland Ltd