Biology Faculty Articles
Title
Viral Interactions with the Nuclear Transport Machinery: Discovering and Disrupting Pathways
Document Type
Article
Publication Date
2-1-2005
Publication Title
International Union of Biochemistry and Molecular Biology (IUBMB) Life
Keywords
Nuclear pore complex, karyopherin, importin, exportin, nuclear transport, VSV, Interferon, TAP
ISSN
1521-6543
Volume
57
Issue/No.
2
First Page
65
Last Page
72
Abstract
Viruses have been invaluable tools for discovering key pathways of nucleocytoplasmic transport. Conversely, disruption of specific nuclear transport pathways, are crucial for the productive life cycle of some viruses. The major cellular mRNA export pathway, which uses TAP (NXF1)/p15(NXT) as receptor, was discovered as a result of TAP interaction with CTE-containing RNAs from Mason-Pfizer Monkey Virus. In addition, CRM1 or exportin 1, which is a transport receptor that mediates nuclear export of proteins, snRNAs, rRNAs and a small subset of mRNAs, was discovered as an interacting partner of the Rev protein of HIV1. Viruses may disrupt the nuclear transport machinery to prevent host antiviral response. VSV Matrix (M) protein inhibits mRNA export by forming a complex with the mRNA export factor Rae1 whereas poliovirus inhibits nuclear import of proteins by probably degrading Nup62 and Nup153. Hence, this review focuses on viruses as tools and as disruptors of nucleocytoplasmic trafficking.
NSUWorks Citation
Fontoura, Beatriz M. A.; Paula A. Faria Waziry; and Daniel R. Nussenzveig. 2005. "Viral Interactions with the Nuclear Transport Machinery: Discovering and Disrupting Pathways." International Union of Biochemistry and Molecular Biology (IUBMB) Life 57, (2): 65-72. https://nsuworks.nova.edu/cnso_bio_facarticles/79
