Title

Genetics of HIV-1 Infection: Chemokine Receptor Ccr5 Polymorphism and its Consequences

Authors

Mary Carrington, National Cancer Institute at Frederick
Michael Dean, National Cancer Institute at Frederick
Maureen P. Martin, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

1999

Publication Title

Human Molecular Genetics

ISSN

0964-6906

Volume

8

Issue/No.

10

First Page

1939

Last Page

1945

Abstract

The chemokine receptor gene, CCR5, has become a central theme in studies of host genetic effects on HIV-1 pathogenesis ever since the discovery that the CCR5 molecule serves as a major cell surface co-receptor for the virus. A growing number of genetic variants within the coding and 5′ regulatory region of CCR5 have been identified, several of which have functional consequences for HIV-1 pathogenesis. Here we review the CCR5 literature describing CCR5 polymorphism and the functional ramifications that several of these variants have on HIV-1 infection and progression to AIDS. The multiplicity of CCR5 genetic effects on HIV-1 disease underscores the critical importance of this gene in controlling AIDS pathogenesis and provides the logic for development of therapeutic strategies that target the interaction of HIV-1 envelope and CCR5 in HIV-1 associated disease.

Comments

©1999 Oxford University Press

Additional Comments

NCI contract #: NO1-CO-56000

NSUWorks Citation

Carrington, Mary; Michael Dean; Maureen P. Martin; and Stephen J. O'Brien. 1999. "Genetics of HIV-1 Infection: Chemokine Receptor Ccr5 Polymorphism and its Consequences." Human Molecular Genetics 8, (10): 1939-1945. https://nsuworks.nova.edu/cnso_bio_facarticles/646

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015