Association of Polymorphisms in Human Leukocyte Antigen Class I and Transporter Associated with Antigen Processing Genes with Resistance to Human Immunodeficiency Virus Type 1 Infection
Journal of Infectious Diseases
To examine the relationship of human leukocyte antigen (HLA) class I and transporter associated with antigen processing (TAP) genes with resistance to human immunodeficiency virus type 1 (HIV-1) infection, 100 HIV-seronegative men who had been exposed repeatedly to HIV-1 were compared with 184 men who had seroconverted to HIV positive and had lower risk. In the univariate analysis, the HLA-A2 supertype, excluding A*0201 (HLA-A2/6802 supertype; odds ratio [OR], 4.45; 95% confidence interval [CI], 1.33–4.84; P = .009) was associated with resistance to HIV-1 infection; the effect was the result of the presence of the A*0205 subgroup alleles. Susceptibility was associated in univariate analysis with the B*35 Px alleles (OR, 0.29; 95% CI, 0.08–0.99; P = .037), which suggests that differential preferences for amino acids at the C terminus may influence peptide-binding capacity. TAP2 Ala665 was also associated with resistance (OR, 2.26; 95% CI, 1.35–3.79; P = .002), perhaps because of its higher efficiency in transporting peptides, thus eliciting a greater CD8+ T cell response, or because of linkage disequilibrium. In multivariate logistic analysis, only the A*0205 subgroup (OR, 5.56; 95% CI, 1.34–23.10; P = .018) and the TAP2 Ala665 (OR, 2.22; 95% CI, 1.28–3.84; P = .005) were associated with resistance.
Liu, Chenglong; Mary Carrington; Richard A. Kaslow; Xiaojiang Gao; Charles Rinaldo; Lisa Jacobson; Joseph Margolick; John Phair; Stephen J. O'Brien; and Roger Detels. 2003. "Association of Polymorphisms in Human Leukocyte Antigen Class I and Transporter Associated with Antigen Processing Genes with Resistance to Human Immunodeficiency Virus Type 1 Infection." Journal of Infectious Diseases 187, (9): 1404-1410. https://nsuworks.nova.edu/cnso_bio_facarticles/607