Title

MICA and Recovery from Hepatitis C Virus and Hepatitis B Virus Infections

Authors

Peter Karacki, Johns Hopkins Medical Institutions
Xiaojiang Gao, National Cancer Institute at Frederick
Chloe L. Thio, Johns Hopkins Medical Institutions
D. L. Thomas, National Cancer Institute at Frederick; Johns Hopkins Medical Institutions
James J. Goedert, National Cancer Institute at Rockville
David Vlahov, Johns Hopkins Medical Institutions; New York Academy of Medicine
Richard A. Kaslow, University of Alabama - Birmingham
Steffanie A. Strathdee, Johns Hopkins Medical Institutions
Margaret Hilgartner, New York Presbyterian Hospital - Cornell Medical Center
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Mary Carrington, National Cancer Institute at Frederick

Document Type

Article

Publication Date

6-2004

Publication Title

Genes and Immunity

Keywords

HCV, HBV, MICA, Genetics, Viral persistence, Pathogenesis

ISSN

1466-4879

Volume

5

Issue/No.

4

First Page

261

Last Page

266

Abstract

The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8⁺ T cells and natural killer (NK) cells. We hypothesized that MICA heterogeneity would affect recovery from hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To test the hypothesis, we initially typed known MICA polymorphisms for 228 persons who cleared HCV infection and 442 persons with persistent hepatitis C matched on other factors affecting viral persistence. Although MICA*015 was detected more than two-fold more often in persons with viral clearance (odds ratio 0.36, 95% confidence interval=0.19, 0.80), it occurred in fewer than 5% of the study population. In a similar analysis of 442 persons with chronic hepatitis B and 768 matched controls who recovered, MICA*015 was detected in 2.0% of persons with chronic hepatitis B and only 0.9% of controls. No significant associations were detected with other MICA polymorphisms. While further investigation may reveal a structural basis of the MICA*015 associations, these data provide little support for the hypothesis that differential distribution of MICA alleles substantially affects recovery from HCV and HBV infections.

Comments

©2004 Nature Publishing Group

Additional Comments

NIH grant #s: DA00441, DA04334, DA13324; National Institute of Allergy and Infectious Diseases grant #s: UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041; National Cancer Institute contract #s: N01-CP-33002, NO1-CO-56000

NSUWorks Citation

Karacki, Peter; Xiaojiang Gao; Chloe L. Thio; D. L. Thomas; James J. Goedert; David Vlahov; Richard A. Kaslow; Steffanie A. Strathdee; Margaret Hilgartner; Stephen J. O'Brien; and Mary Carrington. 2004. "MICA and Recovery from Hepatitis C Virus and Hepatitis B Virus Infections." Genes and Immunity 5, (4): 261-266. https://nsuworks.nova.edu/cnso_bio_facarticles/563

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015