Biology Faculty Articles
Title
Mitochondrial DNA Haplogroups Influence AIDS Progression
Document Type
Article
Publication Date
11-30-2008
Publication Title
AIDS
Keywords
AIDS, Apoptosis, Disease, HIV-1, Mitochondria
ISSN
0269-9370
Volume
22
Issue/No.
18
First Page
2429
Last Page
2439
Abstract
Objective: Mitochondrial function plays a role in both AIDS progression and HAART toxicity; therefore, we sought to determine whether mitochondrial DNA variation revealed novel AIDS restriction genes, particularly as mitochondrial DNA singlenucleotide polymorphisms are known to influence regulation of oxidative phosphorylation, reactive oxygen species production, and apoptosis.
Design: This is a retrospective cohort study. Methods: We performed an association study of mitochondrial DNA haplogroups among 1833 European American HIV-1 patients from five US cohorts: the Multicenter AIDS Cohort Study, the San Francisco City Clinic Study, Hemophilia Growth and Development Study, the Multicenter Hemophilia Cohort Study, and the AIDS Linked to Intravenous Experiences cohort to determine whether the mitochondrial DNA haplogroup correlated with AIDS progression rate.
Results: Mitochondrial DNA haplogroups J and U5a were elevated among HIV-1 infected people who display accelerated progression to AIDS and death. Haplogroups Uk, H3, and IWX appeared to be highly protective against AIDS progression.
Conclusion: The associations found in our study appear to support a functional explanation by which mitochondrial DNA variation among haplogroups, influencing ATP production, reactive oxygen species generation, and apoptosis, is correlated to AIDS disease progression; however, repeating these results in cohorts with different ethnic backgrounds would be informative. These data suggest that mitochondrial genes are important indicators of AIDS disease progression in HIV-1 infected persons.
Additional Comments
National Cancer Institute contract #s: N01-CO-12400, UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041, N02- CP-55504; Spanish Fondo de Investigacion Sanitaria grant #: FIS-PI05-0647; NIH grant #s: R01 AG24373, DK7369
NSUWorks Citation
Hendrickson, Sher L.; Holli Hutcheson; Eduardo Ruiz-Pesini; Jason C. Poole; J. A. Lautenberger; Efe Sezgin; Lawrence Kingsley; James J. Goedert; David Vlahov; Sharyne Donfield; Douglas C. Wallace; and Stephen J. O'Brien. 2008. "Mitochondrial DNA Haplogroups Influence AIDS Progression." AIDS 22, (18): 2429-2439. https://nsuworks.nova.edu/cnso_bio_facarticles/490
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©2008 Wolters Kluwer Health