Biology Faculty Articles
Title
Feline Immunodeficiency Virus (FIV) in Wild Pallas' Cats
Document Type
Article
Publication Date
3-15-2010
Publication Title
Veterinary Immunology and Immunopathology
Keywords
FIV, Pallas’ cat, Evolution, Histopathology, Felidae
ISSN
0165-2427
Volume
134
Issue/No.
1-2
First Page
90
Last Page
95
Abstract
Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas’ cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIVOma in natural populations. Here, a 25% seroprevalence of FIV is reported from 28 wild Mongolian Pallas’ cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIVOma isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas’ cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas’ cats suggests that FIVOma causes immune depletion in its’ native host.
Additional Comments
National Cancer Institute contract #: N01-CO-12400; GenBank accession #s: GQ370820-GQ370824
NSUWorks Citation
Brown, Meredith; Bariushaa Munkhtsog; Jennifer L. Troyer; Steve Ross; Rani Sellers; Amanda E. Fine; William Swanson; Melody E. Roelke; and Stephen J. O'Brien. 2010. "Feline Immunodeficiency Virus (FIV) in Wild Pallas' Cats." Veterinary Immunology and Immunopathology 134, (1-2): 90-95. https://nsuworks.nova.edu/cnso_bio_facarticles/461
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©2009 Elsevier B.V. All rights reserved.