The Lake Casitas Wild Mouse: Evolving Genetic Resistance to Retroviral Disease
Trends in Genetics
A small colony of feral mice from California continues to flourish in spite of virulent epizootic of pathological retrovirus. Epidemiological and genetic studies revealed that the viral infection is strongly balanced by the polymorphic resistance locus, Fv-4, a transcriptionally active but truncated provirus that originated in the East Asian ancestors of the Californian mice. The natural history of these populations represents a graphic example of genomic adaptation in free-ranging populations to regulate and delimit infectious disease.
Gardner, Murray B.; Christine Kozak; and Stephen J. O'Brien. 1991. "The Lake Casitas Wild Mouse: Evolving Genetic Resistance to Retroviral Disease." Trends in Genetics 7, (1): 22-27. https://nsuworks.nova.edu/cnso_bio_facarticles/343