Title

A Common Proviral Integration Region, fit-1, in T-Cell Tumors Induced by Myc-Containing Feline Leukemia Viruses

Authors

Hajime Tsujimoto, University of Tokyo
Ruth Fulton, Beatson Institute for Cancer Research - Bearsden, Scotland
Yasunobu Matusomoto, University of Tokyo
Kazuo Nishigaki, University of Tokyo
Atsuhiko Hasegawa, University of Tokyo
Atsumi Tsujimoto, University of Tokyo
Stanley Cevario, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Anne Terry, University of Glasgow
David Onions, University of Glasgow
James C. Neil, University of Glasgow

Document Type

Article

Publication Date

10-1993

Publication Title

Virology

ISSN

0042-6822

Volume

196

Issue/No.

2

First Page

845

Last Page

848

Abstract

Feline leukemia viruses carrying transduced v-myc genes (myc-FeLV) induce tumors of clonel origin, suggesting that activated myc alone is not sufficient for tumorgenesis. To investigate the hypothesis that insertional mutagenesis plays a role by activating genes which collaborate with v-myc, we looked for evidence of common proviral integration sites in these tumors. By inverse polymerase chain reaction we identified a 6-kb domain, designated fit-1, in which FeLV proviruses were inserted in four of nine (44%) T-cell tumors induced by myc-FeLV. The fit-1 locus was mapped to feline chromosome B2 and appears to be distinct from known oncogenes located on this chromosome. Fit-1 represents a novel common proviral integration region which may harbor a cellular gene which acts in concert with the myc gene in T-cell tumorigenesis.

Comments

© 1993 Academic Press. All rights reserved.

NSUWorks Citation

Tsujimoto, Hajime; Ruth Fulton; Yasunobu Matusomoto; Kazuo Nishigaki; Atsuhiko Hasegawa; Atsumi Tsujimoto; Stanley Cevario; Stephen J. O'Brien; Anne Terry; David Onions; and James C. Neil. 1993. "A Common Proviral Integration Region, fit-1, in T-Cell Tumors Induced by Myc-Containing Feline Leukemia Viruses." Virology 196, (2): 845-848. https://nsuworks.nova.edu/cnso_bio_facarticles/268

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015