Akvr-1, a Dominant Murine Leukemia Virus Restriction Gene, is Polymorphic in Leukemia-Prone Wild Mice
Proceedings of the National Academy of Sciences of the United States of America
Murine leukemia virus regulation, Retrovirus control gene
We describe a restriction gene (Akvr-1, for AKR virus restriction) that is polymorphic for two alleles, Akvr-1R (restrictive) and Akvr-1r (susceptible), in a feral population of mice (Mus musculus domesticus) at a squab farm near Lake Casitas (LC) in southern California. Akvr-1R is a dominant allele that exhibits 100% penetrance in prevention of viremia of AKR endogenous retrovirus and of virus-mediated lymphoma in LC (Akvr-1RR) X AKR F1 hybrids. The restriction phenotype segregates as a single Mendelian locus in backcrosses to AKR mice. Akvr-1R likewise is effective in restriction of NB-tropic Moloney murine leukemia virus-induced viremia and NB-tropic Friend virus-induced splenomegaly but fails to restrict expression or pathogenesis of LC-derived amphotropic retrovirus. Pleiotropic restriction of AKR, Friend, and Moloney ecotropic viruses, but not of amphotropic virus, suggests that the viral targets of Akvr-1 in the three ecotropic viruses are similar to each other and distinct from the target in the LC-amphotropic virus. The relationship of Akvr-1 to previously reported murine restriction loci Fv-1, Fv-2, and Fv-4 is discussed.
Gardner, Murray B.; Suraiya Rasheed; BIjay K. Pal; John D. Estes; and Stephen J. O'Brien. 1980. "Akvr-1, a Dominant Murine Leukemia Virus Restriction Gene, is Polymorphic in Leukemia-Prone Wild Mice." Proceedings of the National Academy of Sciences of the United States of America 77, (1): 531-535. doi:10.1073/pnas.77.1.531.