Title

Genetic Mapping of Endogenous RD-114 Retroviral Sequences of Domestic Cats

Authors

Roger H. Reeves, National Cancer Institute at Frederick
William G. Nash, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

10-1985

Publication Title

Journal of Virology

ISSN

0022-538X

Volume

56

Issue/No.

1

First Page

303

Last Page

306

Abstract

The RD-114 family of endogenous retroviral sequences in domestic cats has been shown to consist of approximately 20 copies of genetically divergent virogenes per haploid genome. The chromosomal localization for four endogenous sequences (RDV1-4) was accomplished by correlating the occurrence of specific feline chromosomes with diagnostic viral DNA fragments in a panel of cat x rodent somatic cell hybrids. Analysis of the hybrid panel revealed that endogenous RD-114 sequences are dispersed on multiple cat chromosomes, that certain proviral segments are polymorphic with respect to the presence or absence of virus, and that a restriction fragment characteristic of inducible RD-114 resides on a single feline chromosome (B3), probably at a single locus.

Comments

©1985, American Society for Microbiology

Additional Comments

Damon Runyon-Walter Winchell Cancer Fund: DRG835

NSUWorks Citation

Reeves, Roger H.; William G. Nash; and Stephen J. O'Brien. 1985. "Genetic Mapping of Endogenous RD-114 Retroviral Sequences of Domestic Cats." Journal of Virology 56, (1): 303-306. https://nsuworks.nova.edu/cnso_bio_facarticles/221

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015