Biology Faculty Articles
The Human Homologs of the raf (mil) Oncogene are Located on Human Chromosomes 3 and 4
Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.
Bonner, Tom I.; Stephen J. O'Brien; William Nash; Ulf R. Rapp; Cynthia C. Morton; and Philip Leder. 1984. "The Human Homologs of the raf (mil) Oncogene are Located on Human Chromosomes 3 and 4." Science 223, (4631): 71-74. doi:10.1126/science.6691137.
©1984 American Association for the Advancement of Science